User profiles for H. Farne
 | Hugo FarneImperial College Verified email at imperial.ac.uk Cited by 1858 |
Anti‐IL‐5 therapies for asthma
Background This is the second update of previously published reviews in the Cochrane
Library (2015, first update 2017). Interleukin‐5 (IL‐5) is the main cytokine involved in the …
Library (2015, first update 2017). Interleukin‐5 (IL‐5) is the main cytokine involved in the …
Long‐acting beta2‐agonist in addition to tiotropium versus either tiotropium or long‐acting beta2‐agonist alone for chronic obstructive pulmonary disease
HA Farne, CJ Cates - Cochrane database of systematic …, 2015 - cochranelibrary.com
Long‐acting beta2‐agonist in addition to tiotropium versus either tiotropium or long‐acting
beta2‐agonist alone for chronic obstructive pulmonary disease - Farne, HA - 2015 | Cochrane …
beta2‐agonist alone for chronic obstructive pulmonary disease - Farne, HA - 2015 | Cochrane …
The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma
Asthma and chronic obstructive pulmonary disease (COPD) are major causes of global
morbidity and mortality worldwide. The clinical course of both asthma and COPD are punctuated …
morbidity and mortality worldwide. The clinical course of both asthma and COPD are punctuated …
[HTML][HTML] Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
Background The mechanisms underlying altered susceptibility and propensity to severe
Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with chronic …
Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with chronic …
A persistent neutrophil-associated immune signature characterizes post–COVID-19 pulmonary sequelae
… (H) Correlation between plasma proteins and extent of radiographic changes on CT
scanning is shown. Correlations were determined by Spearman’s rank correlation test. …
scanning is shown. Correlations were determined by Spearman’s rank correlation test. …
Ability of King's College criteria and model for end-stage liver disease scores to predict mortality of patients with acute liver failure: a meta-analysis
MJW McPhail, H Farne, N Senvar, JA Wendon… - Clinical …, 2016 - Elsevier
Background & Aims Several prognostic factors are used to identify patients with acute liver
failure (ALF) who require emergency liver transplantation. We performed a meta-analysis to …
failure (ALF) who require emergency liver transplantation. We performed a meta-analysis to …
Pathogenesis of viral infection in exacerbations of airway disease
Chronic airway diseases are a significant cause of morbidity and mortality worldwide, and
their prevalence is predicted to increase in the future. Respiratory viruses are the most …
their prevalence is predicted to increase in the future. Respiratory viruses are the most …
[HTML][HTML] Increased airway glucose increases airway bacterial load in hyperglycaemia
SK Gill, K Hui, H Farne, JP Garnett, DL Baines… - Scientific reports, 2016 - nature.com
Diabetes is associated with increased frequency of hospitalization due to bacterial lung
infection. We hypothesize that increased airway glucose caused by hyperglycaemia leads to …
infection. We hypothesize that increased airway glucose caused by hyperglycaemia leads to …
[HTML][HTML] Obesity dysregulates the pulmonary antiviral immune response
… 48 h, CXCL10/IP-10 at 24 h and TNF at 48 h after presentation, all compared to non-obese
patients (Fig. 6c). By contrast, there were no significant differences in serum concentrations of …
patients (Fig. 6c). By contrast, there were no significant differences in serum concentrations of …
[HTML][HTML] Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease
Background Patients with chronic obstructive pulmonary disease (COPD) have increased
susceptibility to respiratory tract infection, which contributes to disease progression and …
susceptibility to respiratory tract infection, which contributes to disease progression and …