Background Exacerbations are a key outcome in clinical research, providing patient-relevant
information about symptomatic control, health state and disease progression. Generally …

Importance The house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet is
a potential novel treatment option for HDM allergy–related asthma. Objectives To evaluate …

Oxycodone is an opioid analgesic that is administered orally or parenterally. The time-course
of opioid action is a function of the systemic kinetics of the opioid, and the rate and extent of …

Background An increased and prolonged duration of pain relief after morphine administration
has been found in elderly patients. Whether this is due to alterations in pharmacokinetics, …

Background: Relieving distressing symptoms and managing the side effects of analgesics
are essential in order to improve quality of life and functional capacity in chronic non‐cancer …

Objective The aim of this investigation was to characterize the pharmacokinetics of
buprenorphine following administration of an intravenous (iv) infusion. To date, the population …

… AO Birk, JS Andersen, HH Villesen, and MA Steffensen are employed by ALK. MA Calderon
has received consultancy and lecture fees from ALK, Stallergenes, Merck, Allergopharma, …

… Villesen … In the present study, the plasma concentration peaks after 50 mg occurred
slightly later than previously published by Villesen et al. (t 1 : 3.5 vs. 2.5; t 2 : 21.3 vs. …

BACKGROUND: The active metabolite of morphine, morphine-6-glucuronide (M6G), shows
an analgesic effect that is equivalent to morphine. The bioavailability is low (11–13%) when …

Background and purpose: At present there are few data regarding the rate and extent of
brain–blood partitioning of the opioid active metabolite of morphine, morphine‐6‐glucuronide (…