Th2 cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells

…, B Marku, MR Edwards, LA Stanciu, G Gnesini… - Allergy, 2015 - Wiley Online Library
Background Asthma and other Th2 inflammatory conditions have been associated with
increased susceptibility to viral infections. The mechanisms by which Th2 cytokines can influence …

Long-term effects of inhaled corticosteroids on sputum bacterial and viral loads in COPD

…, A Marcellini, G Forini, G Gnesini… - European …, 2017 - Eur Respiratory Soc
Inhaled corticosteroid-containing medications reduce the frequency of COPD exacerbations
(mainly infectious in origin) while paradoxically increasing the risk of other respiratory …

Airway inflammatory profile is correlated with symptoms in stable COPD: A longitudinal proof‐of‐concept cohort study

M Contoli, S Baraldo, V Conti, G Gnesini, B Marku… - …, 2020 - Wiley Online Library
Background and objective Symptoms negatively impact the quality of life and long‐term
prognosis of patients with chronic obstructive pulmonary disease (COPD). Little is known about …

[HTML][HTML] Reducing agents decrease the oxidative burst and improve clinical outcomes in COPD patients: a randomised controlled trial on the effects of sulphurous …

M Contoli, G Gnesini, G Forini, B Marku… - The Scientific World …, 2013 - hindawi.com
Background. Inhalation of thermal water with antioxidant properties is empirically used for
COPD. Aims. To evaluate the effects of sulphurous thermal water (reducing agents) on airway …

Midazolam in flexible bronchoscopy premedication: effects on patient-related and procedure-related outcomes

M Contoli, G Gnesini, D Artioli, C Ravenna… - … of Bronchology & …, 2013 - journals.lww.com
Background: The role of midazolam in flexible bronchoscopy premedication has been
debated. The aim of the present study was to evaluate whether midazolam premedication …

Assessing small airway impairment in mild-to-moderate smoking asthmatic patients

…, G Forini, S Bianchi, G Gnesini… - European …, 2016 - Eur Respiratory Soc
Asthma is characterised by airway inflammation throughout the bronchial tree, including the
small airways. In asthma, small airway alterations are associated with poor clinical outcomes …

Midazolam in the fiber-optic bronchoscopy premedication: effects on patient-related and procedure-related outcomes

…, M Contoli, E Marangoni, C Romanazzi, G Gnesini… - Chest, 2011 - journal.chestnet.org
PURPOSE: The role of Midazolam (a short-acting benzodiazepine), in the flexible bronchoscopy
premedication is debated. Indeed, there is evidence that sedative medications increase …

Expression and activation of the major subunit of NF-kB, protein p65, in COPD bronchial glands

…, J Marwick, S Giuffrè, M Contoli, G Gnesini… - EUROPEAN …, 2009 - iris.unime.it
Activation of NF-kB is involved in the regulation of many inducible genes that encode for
inflammatory proteins potentially relevant to the pathogenesis of chronic obstructive pulmonary …

Long-term effects of inhaled corticosteroids on sputum bacterial and viral loads in COPD 2

…, G Gnesini, B Marku, N Barnes, A Rizzi, G Curradi… - Methods - Eur Respiratory Soc
… Reijans M, Dingemans G, Klaassen CH, Meis JF, Keijdener J, Mulders B, Eadie K, van
Leeuwen W, van Belkum A, Horrevorts AM, Simons G. RespiFinder: a new multiparameter …

Small airway impairment in severe asthmatic patients

…, L Morandi, F Bellini, S Soave, G Forini, G Gnesini… - 2018 - Eur Respiratory Soc
Introduction: small-airway impairments contribute to the severity of the clinical manifestation
of asthma. Small airway abnormalities are key elements in the pathogenesis of COPD Aims: …