… pneumoniae as well as not changing the breakpoint for penicillin G for this pathogen 23,24 .
… comparisons of different dosing regimens of penicillin G against penicillin-susceptible and -…

Infections in critically ill patients are associated with persistently poor clinical outcomes. These
patients have severely altered and variable antibiotic pharmacokinetics and are infected …

Interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics (PD)
of antimicrobial agents has increased over recent years. Since the appearance 2 years …

Since the advent of the modern era of antimicrobial chemotherapy in the 1930s, animal
infection models have allowed for the in vivo evaluation of antimicrobial agents for the treatment …

… vancomycin (26 patients taking ≥4 g/day and 220 patients taking <4 g/day) and 45 patients
… between patients receiving ≥4 g vancomycin/day, those receiving <4 g vancomycin/day, …

… piperacillin-tazobactam (3.375 g intravenously for 30 min every 4 or 6 h); after this time, all
patients received extended infusions of piperacillin-tazobactam (3.375 g intravenously for 4 h …

Context.—One purpose of early clinical trials is to establish the appropriate dose of an antibiotic
for phase 3 trials. Development of a relationship between the ratio of drug exposure to …

… We recently reported that the vancomycin regimens (ie, ⩾4 g of vancomycin per day) that
were used to achieve this higher trough value are associated with an elevated risk of …

… g) and for all infusion times after an expectation is taken over the full P. aeruginosa MIC … It
is important that one can safely administer a dosage of 2 g iv q8h of meropenem. It is obvious …

The nephrotoxicity and ototoxicity associated with once-daily versus twice-daily
administration of aminoglycosides was assessed in patients with suspected or proven gram-negative …