The pharmacokinetic and pharmacodynamic effects of inhaled corticosteroids (ICS) have
shaped the efficacy and safety of these agents in the treatment of asthma. Important …

Chronic obstructive pulmonary disease (COPD) is a progressive disease that begins many
years before a diagnosis is usually made. The need for an early and confirmed diagnosis of …

FKBP ligand homodimers can be used to activate signaling events inside cells and animals
that have been engineered to express fusions between appropriate signaling domains and …

Gene therapy was originally conceived as a medical intervention to replace or correct defective
genes in patients with inherited disorders. However, it may have much broader potential …

… tightly to F M [dissociation constant (K d ) ≈ 1 nM)] but negligibly to endogenous wild-type
FKBP12 (Fig. 1B) (7). Secreted F M fusion proteins are retained in the ER. To determine if F M …

Inhaled corticosteroids (ICS) are the standard of care in asthma and are widely used in the
treatment of patients with chronic obstructive pulmonary disease. High-dose regimens and …

Stable delivery of a therapeutic protein under pharmacologic control was achieved through
in vivo somatic gene transfer. This system was based on the expression of two chimeric, …

… for each k-point in the BZ, f 0 is the equilibrium distribution function, and ∊ is the electron
energy. … n Ω n z ( k ) is the sum of the Berry curvature over the occupied bands ( f n is the Fermi–…

The influence of climate on the distribution of taxa has been extensively investigated in the
last two decades through Habitat Suitability Models (HSMs). In this context, the Worldclim …

Effective delivery of secreted proteins by gene therapy will require a vector that directs stable
delivery of a transgene and a regulatory system that permits pharmacologic control over the …