User profiles for E. Seydoux

Emilie Seydoux

University Hospital Bern, University of Bern, Switzerland
Verified email at insel.ch
Cited by 1849

mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection

…, V Rubin, H Glantz, M Neradilek, E Seydoux… - Science, 2021 - science.org
… (A to E) The ability of the indicated mAbs to neutralize Wuhan-Hu-1, B.1.351, and B.1.351–Δ242-243
pseudovirus infectivity in 293T-hACE2 cells was measured as indicated. The …

[PDF][PDF] Analysis of a SARS-CoV-2-infected individual reveals development of potent neutralizing antibodies with limited somatic mutation

E Seydoux, LJ Homad, AJ MacCamy, KR Parks… - Immunity, 2020 - cell.com
Antibody responses develop following SARS-CoV-2 infection, but little is known about their
epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We …

[HTML][HTML] Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

NK Hurlburt, E Seydoux, YH Wan, VV Edara… - Nature …, 2020 - nature.com
SARS-CoV-2 is a betacoronavirus virus responsible for the COVID-19 pandemic. Here, we
determine the X-ray crystal structure of a potent neutralizing monoclonal antibody, CV30, …

[PDF][PDF] Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects

…, NR Akins, J Feng, LJ Homad, NK Hurlburt, E Seydoux… - Cell reports, 2021 - cell.com
SARS-CoV-2 is one of three coronaviruses that have crossed the animal-to-human barrier
and caused widespread disease in the past two decades. The development of a universal …

[HTML][HTML] Interaction of biomedical nanoparticles with the pulmonary immune system

F Blank, K Fytianos, E Seydoux… - Journal of …, 2017 - Springer
… Another macrophage phenotype consists of anti-inflammatory macrophages that are induced
by compounds and mediators such as corticosteroids, IL-10, or prostaglandin E 2 PGE 2 . …

Size-dependent uptake of particles by pulmonary antigen-presenting cell populations and trafficking to regional lymph nodes

F Blank, PA Stumbles, E Seydoux, PG Holt… - American journal of …, 2013 - atsjournals.org
The respiratory tract is an attractive target organ for novel diagnostic and therapeutic
applications with nano-sized carriers, but their immune effects and interactions with key resident …

Current in vitro approaches to assess nanoparticle interactions with lung cells

…, B Drasler, F Blank, C Von Garnier, E Seydoux… - …, 2016 - Future Medicine
The respiratory tract is in constant contact with inhaled antigens from the external environment.
In order to shape its line of defense, it is populated by various types of immune cells. …

[HTML][HTML] Characterization of neutralizing antibodies from a SARS-CoV-2 infected individual

E Seydoux, LJ Homad, AJ MacCamy, KR Parks… - BioRxiv, 2020 - ncbi.nlm.nih.gov
B cells specific for the SARS-CoV-2 S envelope glycoprotein spike were isolated from a
COVID-19-infected subject using a stabilized spike-derived ectodomain (S2P) twenty-one days …

[HTML][HTML] Reprogramming the adjuvant properties of aluminum oxyhydroxide with nanoparticle technology

MT Orr, AP Khandhar, E Seydoux, H Liang, E Gage… - npj Vaccines, 2019 - nature.com
Aluminum salts, developed almost a century ago, remain the most commonly used adjuvant
for licensed human vaccines. Compared to more recently developed vaccine adjuvants, …

Antibodies elicited by SARS-CoV-2 infection and boosted by vaccination neutralize an emerging variant and SARS-CoV-1

…, V Rubin, H Glantz, M Neradilek, E Seydoux… - MedRxiv, 2021 - medrxiv.org
The emergence of SARS-CoV-2 variants raises concerns about their resistance to neutralizing
antibodies elicited from previous infection, or from vaccination. Here we examined …