Despite tremendous advances over the last 15 years in understanding fundamental
mechanisms of apoptosis, this has failed to translate into improved cancer therapy for patients. …

The epidermis is a multilayered stratified epithelium, continuously regenerated by
differentiating keratinocytes, that requires the transcription factor p63 for its development and …

Background— Pollution by particulates has been consistently associated with increased
cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects …

Apoptosis, a major form of cell death, is characterized by chromatin condensation, a
reduction in cell volume and endonuclease cleavage of DNA into oligonucleosomal length …

The mechanisms leading to neuronal death in neurodegenerative disease are poorly
understood. Many of these disorders, including Alzheimer’s, Parkinson’s and prion diseases, are …

… (C and D) CQ potentiates the effect of IM in clonogenic assays of parental (C) and IM-resistant
(D) K562 cells. Cells were plated in methylcellulose in the absence or in the presence of …

Particulate air pollution is associated with cardiovascular morbidity and mortality. To
investigate this association, we studied the effect of ultrafine (60 nm) polystyrene particles on …

Epidermal development requires the transcription factor p63, as p63−/− mice are born dead,
without skin. The gene expresses two proteins, one with an amino-terminal transactivation …

The aggressiveness of glioblastoma multiforme (GBM) is defined by local invasion and
resistance to therapy. Within established GBM, a subpopulation of tumor-initiating cells with stem-…

Background— Pollution by particulates has consistently been associated with increased
cardiovascular morbidity and mortality, but a plausible biological basis for this association is …