Importance in the field: Activated cells metabolize albumin to cover their increased need for
amino acids and energy. In inflamed, diseased and malignant tissue, extravasation of …

Background Long-term immunosuppressive treatment does not efficiently prevent relapses
of lupus nephritis (LN). This investigator-initiated randomised trial tested whether …

Objective Fatigue is reported in up to 90% of patients with SLE. This study was conducted to
identify the determinants associated with fatigue in a large cohort of patients with SLE, as …

Objectives To determine the burden of major musculoskeletal conditions and limb trauma in
terms of mortality and disability. Methods A Scientific Group meeting of experts in the areas …

Objectives Familial chilblain lupus is a monogenic form of cutaneous lupus erythematosus
caused by loss-of-function mutations in the nucleases TREX1 or SAMHD1. In a family without …

Objective: To evaluate the differences in the outcome of lupus nephritis diagnosed either in
the 1980s or the 1990s in Heidelberg, Germany. Methods: Fifteen patients with biopsy …

Introduction Evidence from a number of open-label, uncontrolled studies has suggested that
rituximab may benefit patients with autoimmune diseases who are refractory to standard-of-…

Objective. Systemic sclerosis (SSc) is a rare, heterogeneous disease, which affects different
organs and therefore requires interdisciplinary diagnostic and therapeutic management. To …

Objective CD4+,CD25 high regulatory T (Treg) cells play a crucial role in the maintenance of
self tolerance and prevention of organ‐specific autoimmunity. The presence of many in vivo…

Introduction In the present study, we analysed in detail nuclear autoantibodies and their
associations in systemic sclerosis (SSc) patients included in the German Network for Systemic …