User profiles for C. Doebele
Robert C. Doebele, MD, PhDUniversity of Colorado, Anschutz Medical Campus Verified email at cuanschutz.edu Cited by 31177 |
DExD/H-box RNA helicases in ribosome biogenesis
R Martin, AU Straub, C Doebele, MT Bohnsack - RNA biology, 2013 - Taylor & Francis
… Citation 17 The expression of CsdA is specifically induced at temperatures below 20C to
facilitate LSU assembly.Citation 18 At low temperatures, lack of CsdA leads to slow growth and …
facilitate LSU assembly.Citation 18 At low temperatures, lack of CsdA leads to slow growth and …
MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice
… (C) Capillary density was determined after intravenous infusion of FITC-conjugated lectin
and was quantified in the remote, border, and infarct regions of the hearts by automatic …
and was quantified in the remote, border, and infarct regions of the hearts by automatic …
Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells
C Doebele, A Bonauer, A Fischer… - Blood, The Journal …, 2010 - ashpublications.org
… that invaded the Matrigel plug in vivo (Figure 2CD), whereas specific blockade of miR-18a,
miR-19a, or mir-20a showed a trend but no significant effect on neovascularization (Figure 2C…
miR-19a, or mir-20a showed a trend but no significant effect on neovascularization (Figure 2C…
MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A
…, RA Boon, A Bonauer, C Doebele… - Blood, The Journal …, 2012 - ashpublications.org
… Forty hours after transfection, 0.5 mg/mL MTT was added to each well, and cells were
incubated for 4 hours at 37C. Cells were washed with PBS and lysed 30 minutes at room …
incubated for 4 hours at 37C. Cells were washed with PBS and lysed 30 minutes at room …
Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension
SS Pullamsetti, C Doebele, A Fischer… - American journal of …, 2012 - atsjournals.org
… After electrophoresis, gels were incubated five times for 15 minutes in renaturation buffer,
followed by overnight incubation in activation buffer at 37C. The next day, gels were stained to …
followed by overnight incubation in activation buffer at 37C. The next day, gels were stained to …
[PDF][PDF] Hoxa9 and Meis1 cooperatively induce addiction to Syk signaling by suppressing miR-146a in acute myeloid leukemia
S Mohr, C Doebele, F Comoglio, T Berg, J Beck… - Cancer cell, 2017 - cell.com
The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene
overexpression but is currently considered undruggable. We therefore investigated whether …
overexpression but is currently considered undruggable. We therefore investigated whether …
Histone deacetylase 9 promotes angiogenesis by targeting the antiangiogenic microRNA-17–92 cluster in endothelial cells
…, Y Manavski, JN Boeckel, C Doebele… - … , and vascular biology, 2013 - Am Heart Assoc
… Embryos were kept in E3 solution at 28.5C with or without 0.003% 1-phenyl-2-thiourea (Sigma-Aldrich)
to suppress pigmentation and staged according to somite number or hours …
to suppress pigmentation and staged according to somite number or hours …
TRKing down an old oncogene in a new era of targeted therapy
A Vaishnavi, AT Le, RC Doebele - Cancer discovery, 2015 - AACR
The use of high-throughput next-generation sequencing techniques in multiple tumor types
during the last few years has identified NTRK1, 2, and 3 gene rearrangements encoding …
during the last few years has identified NTRK1, 2, and 3 gene rearrangements encoding …
Molecular pathways: ROS1 fusion proteins in cancer
KD Davies, RC Doebele - Clinical cancer research, 2013 - AACR
Genetic alterations that lead to constitutive activation of kinases are frequently observed in
cancer. In many cases, the growth and survival of tumor cells rely upon an activated kinase …
cancer. In many cases, the growth and survival of tumor cells rely upon an activated kinase …
SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma
AC Wilke, C Doebele, A Zindel, KS Lee… - Blood, The Journal …, 2022 - ashpublications.org
Burkitt lymphoma (BL) is an aggressive lymphoma type that is currently treated by intensive
chemoimmunotherapy. Despite the favorable clinical outcome for most patients with BL, …
chemoimmunotherapy. Despite the favorable clinical outcome for most patients with BL, …