Psoriatic arthritis (PsA) has been defined as a unique inflammatory arthritis associated with
psoriasis. Its exact prevalence is unknown, but estimates vary from 0.3% to 1% of the …

… The finding that p50/KIR2DS binds HLA-C with lower affinity as compared to its inhibitory
counterpart (116) suggested the existence of a mechanism ensuring that inhibitory signals …

… Secukinumab was associated with a reduction in median C reactive protein (CRP) level from
baseline to week 6 (from 5.0 (range: 0.3, 43.0) to 3.0 (range: 0.2, 15.2)), while with placebo …

Tumour necrosis factor α (TNFα) is a critical inflammatory mediator in rheumatoid arthritis,
and may therefore be a useful target for specific immunotherapy. In support of this hypothesis, …

Objective To evaluate the efficacy, pharmacokinetics, immunogenicity, and safety of multiple
infusions of a chimeric monoclonal anti‐tumor necrosis factor α antibody (cA2) (infliximab; …

Interleukin-17A (IL-17A) is elaborated by the T helper 17 (T H 17) subset of T H cells and
exhibits potent proinflammatory properties in animal models of autoimmunity, including collagen…

… joints and five or more tender joints and either C reactive protein (CRP) levels of at least 15
mg… C Birbara has received research support from Centocor, Inc. We acknowledge C Arnold of …

… c Summary of particle selection and structural analysis using RELION and crYOLO/SPHIRE.
d Representative reference-free 2-D class averages obtained using the ISAC and Beautifier …

Abstract Treatment with a chimeric mAb to TNF-α has been shown to suppress inflammation
and improve patient well-being in rheumatoid arthritis (RA), but the mechanisms of action of …

… Antoni has received consulting fees of less than $10,000 from Centocor and more than
$10,000 from Schering-Plough. Dr. Kavanaugh has received consulting fees of less than …