Allergic diseases are caused by aberrant T-helper-2 immune responses in susceptible
individuals. Both naturally occurring CD4 + CD25 + regulatory T cells and inducible populations …

… thymic-derived CD4+Foxp3+ Treg cells and peripherally antigen-induced adaptive CD4+
Treg cells, which comprise both Foxp3-positive and -negative populations (Hawrylowicz …

… on culture dish diameter, PM per cm 2 surface deposition can vary … μg/cm 2 induced
significantly increased expression of IL8 and PTGS2 whereas re-suspended PM at 2.65 μg/cm 2 did …

Background Genetic differences in immune responses may affect susceptibility to mycobacterial
infection, but no specific genes have been implicated in humans. We studied four …

… CM Hawrylowicz and RL Coffman contributed equally to this … Hawrylowicz is supported by
the National Asthma Campaign … CM Hawrylowicz and RL Coffman contributed equally to this …

We previously reported that human CD4 + Tregs secrete high levels of IL-10 when stimulated
in the presence of dexamethasone and calcitriol (vitamin D3). We now show that following …

The mode of action of Leflunomide, an immunomodulatory drug used in rheumatoid arthritis,
is debated. This study, using 14 C-labeled de novo purine and pyrimidine synthesis …

Background There remains uncertainty about the impact of menopausal hormone therapy (MHT)
on women’s health. A systematic, comprehensive assessment of the effects on multiple …

… One of us (CM Hawrylowicz) has recently demonstrated that following activation, human
platelets are rapidly induced to express a cell associated form of the cytokine Ibl (12). Agonists …

Epidemiologic studies highlight the increasing prevalence of vitamin D deficiency and
insufficiency and its association with an increased risk of autoimmune diseases and poor …