User profiles for B. Brumpton

Ben Michael Brumpton

Associate Professor, HUNT Center for Molecular and Clinical Epidemiology, NTNU, Norway
Verified email at ntnu.no
Cited by 8306

Within family Mendelian randomization studies

NM Davies, LJ Howe, B Brumpton… - Human Molecular …, 2019 - academic.oup.com
Mendelian randomization (MR) is increasingly used to make causal inferences in a wide
range of fields, from drug development to etiologic studies. Causal inference in MR is possible …

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

…, E Bøen, MP Boks, R Bosch, M Brum, BM Brumpton… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …

[HTML][HTML] Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

…, DM Evans, G Davey Smith, C Hayward, B Brumpton… - Nature …, 2022 - nature.com
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification, assortative …

[PDF][PDF] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

…, K Hagen, KB Nilsen, MU Lie, S Børte, B Brumpton… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

The power of genetic diversity in genome-wide association studies of lipids

…, S Sakaue, C Terao, M Kanai, W Zhou, BM Brumpton… - Nature, 2021 - nature.com
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …

[HTML][HTML] Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

…, K Ishigaki, BO Åsvold, MR Brown, B Brumpton… - Nature …, 2022 - nature.com
The discovery of genetic loci associated with complex diseases has outpaced the elucidation
of mechanisms of disease pathogenesis. Here we conducted a genome-wide association …

[PDF][PDF] Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

…, J Karjalainen, M Kurki, M Maasha, BM Brumpton… - Cell Genomics, 2022 - cell.com
Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic
loci across a range of human diseases and traits. However, most biobanks are primarily …

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

…, K Burrows, O Hummel, S Grosche, BM Brumpton… - Nature …, 2017 - nature.com
Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the
same individuals 1 , partly because of a shared genetic origin 2 , 3 , 4 . To identify shared risk …

[HTML][HTML] Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

B Brumpton, E Sanderson, K Heilbron… - Nature …, 2020 - nature.com
Estimates from Mendelian randomization studies of unrelated individuals can be biased
due to uncontrolled confounding from familial effects. Here we describe methods for within-…

Cohort profile update: the HUNT study, Norway

…, SAA Vikjord, BM Brumpton… - International Journal …, 2023 - academic.oup.com
The Trøndelag Health Study (the HUNT Study) is a population-based cohort study of the
adult population in Trøndelag County, Norway. It was previously called the Nord-Trøndelag …