User profiles for B. Brumpton
Ben Michael BrumptonAssociate Professor, HUNT Center for Molecular and Clinical Epidemiology, NTNU, Norway Verified email at ntnu.no Cited by 8306 |
Within family Mendelian randomization studies
Mendelian randomization (MR) is increasingly used to make causal inferences in a wide
range of fields, from drug development to etiologic studies. Causal inference in MR is possible …
range of fields, from drug development to etiologic studies. Causal inference in MR is possible …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
…, E Bøen, MP Boks, R Bosch, M Brum, BM Brumpton… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
[HTML][HTML] Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
…, DM Evans, G Davey Smith, C Hayward, B Brumpton… - Nature …, 2022 - nature.com
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification, assortative …
effects of inherited variation (direct effects), demography (population stratification, assortative …
[PDF][PDF] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
…, K Hagen, KB Nilsen, MU Lie, S Børte, B Brumpton… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
The power of genetic diversity in genome-wide association studies of lipids
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …
[HTML][HTML] Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
…, K Ishigaki, BO Åsvold, MR Brown, B Brumpton… - Nature …, 2022 - nature.com
The discovery of genetic loci associated with complex diseases has outpaced the elucidation
of mechanisms of disease pathogenesis. Here we conducted a genome-wide association …
of mechanisms of disease pathogenesis. Here we conducted a genome-wide association …
[PDF][PDF] Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic
loci across a range of human diseases and traits. However, most biobanks are primarily …
loci across a range of human diseases and traits. However, most biobanks are primarily …
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the
same individuals 1 , partly because of a shared genetic origin 2 , 3 , 4 . To identify shared risk …
same individuals 1 , partly because of a shared genetic origin 2 , 3 , 4 . To identify shared risk …
[HTML][HTML] Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
Estimates from Mendelian randomization studies of unrelated individuals can be biased
due to uncontrolled confounding from familial effects. Here we describe methods for within-…
due to uncontrolled confounding from familial effects. Here we describe methods for within-…
Cohort profile update: the HUNT study, Norway
…, SAA Vikjord, BM Brumpton… - International Journal …, 2023 - academic.oup.com
The Trøndelag Health Study (the HUNT Study) is a population-based cohort study of the
adult population in Trøndelag County, Norway. It was previously called the Nord-Trøndelag …
adult population in Trøndelag County, Norway. It was previously called the Nord-Trøndelag …