User profiles for A. Wellman

Andrew Wellman

Associate Professor of Sleep Medicine, Brigham and Women's Hospital and Harvard …
Verified email at bwh.harvard.edu
Cited by 11215

Exopolysaccharides from lactic acid bacteria: perspectives and challenges

AD Welman, IS Maddox - Trends in biotechnology, 2003 - cell.com
Some lactic acid bacteria (LAB) secrete a polysaccharide polymer. This extracellular
polysaccharide, or ‘exopolysaccharide' (EPS), is economically important because it can impart …

Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets

…, AS Jordan, A Malhotra, A Wellman - American journal of …, 2013 - atsjournals.org
Rationale: The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among
patients but have not been well characterized. Objectives: To define carefully the proportion …

The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study

…, S Purcell, DP White, S Redline, A Wellman - European heart …, 2019 - academic.oup.com
Aims Apnoea–hypopnoea index (AHI), the universal clinical metric of sleep apnoea severity,
poorly predicts the adverse outcomes of sleep apnoea, potentially because the AHI, a …

Ventilatory control and airway anatomy in obstructive sleep apnea

A Wellman, AS Jordan, A Malhotra… - American journal of …, 2004 - atsjournals.org
Ventilatory instability may play an important role in the pathogenesis of obstructive sleep
apnea. We hypothesized that the influence of ventilatory instability in this disorder would vary …

The influence of aging on pharyngeal collapsibility during sleep

…, AS Jordan, NL Chamberlin, S Gautam, A Wellman… - Chest, 2007 - Elsevier
Background Aging increases vulnerability to obstructive sleep apnea (OSA), but the underlying
mechanisms remain unclear. Recent data in awake healthy volunteers show a decrease …

Effect of oxygen in obstructive sleep apnea: role of loop gain

A Wellman, A Malhotra, AS Jordan… - Respiratory physiology …, 2008 - Elsevier
We compared the effect of oxygen on the apnea–hypopnea index (AHI) in six obstructive
sleep apnea patients with a relatively high loop gain (LG) and six with a low LG. LG is a …

Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea

…, RL Owens, A Malhotra, A Wellman - The Journal of …, 2012 - Wiley Online Library
Key points • Obstructive sleep apnoea (OSA) probably results from the interaction of key
pathophysiological traits including compromised pharyngeal anatomy, inadequate upper‐…

Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea

…, RL Owens, DP White, A Wellman… - American journal of …, 2014 - atsjournals.org
Rationale: A low respiratory arousal threshold (ArTH) is one of several traits involved in
obstructive sleep apnea pathogenesis and may be a therapeutic target; however, there is no …

Quantifying the ventilatory control contribution to sleep apnoea using polysomnography

…, DP White, A Malhotra, A Wellman… - European …, 2015 - Eur Respiratory Soc
Elevated loop gain, consequent to hypersensitive ventilatory control, is a primary nonanatomical
cause of obstructive sleep apnoea (OSA) but it is not possible to quantify this in the clinic…

Upper-airway collapsibility and loop gain predict the response to oral appliance therapy in patients with obstructive sleep apnea

…, DP White, GS Hamilton, A Wellman - American journal of …, 2016 - atsjournals.org
Rationale: Oral appliances (OAs) are commonly used as an alternative treatment to continuous
positive airway pressure for patients with obstructive sleep apnea (OSA). However, OAs …