Mechanisms of pleurodesis

F Rodriguez-Panadero, A Montes-Worboys - Respiration, 2012 - karger.com
Pleurodesis aims to obliterate the pleural space by producing extensive adhesion of the
visceral and parietal pleura, in order to control relapse of either pleural effusions (mostly …

[HTML][HTML] Anti-fibrotic effects of pirfenidone and rapamycin in primary IPF fibroblasts and human alveolar epithelial cells

…, J Dorca, A Montes-Worboys - BMC pulmonary …, 2018 - Springer
Background Pirfenidone, a pleiotropic anti-fibrotic treatment, has been shown to slow down
disease progression of idiopathic pulmonary fibrosis (IPF), a fatal and devastating lung …

Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis

KK Mubarak, A Montes-Worboys… - European …, 2012 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is characterised by myofibroblast proliferation leading to
architectural destruction. Neither the origin nor the continued proliferation of myofibroblasts is …

[HTML][HTML] Fibroblast viability and phenotypic changes within glycated stiffened three-dimensional collagen matrices

…, S Estany, A Colom, A Montes-Worboys… - Respiratory …, 2015 - Springer
Background There is growing interest in the development of cell culture assays that enable
the rigidity of the extracellular matrix to be increased. A promising approach is based on three…

[HTML][HTML] Mitochondrial dysfunction in lung resident mesenchymal stem cells from idiopathic pulmonary fibrosis patients

…, G Escarrer-Garau, L Elowsson, A Montes-Worboys… - Cells, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is characterized by an aberrant repair response with
uncontrolled turnover of extracellular matrix involving mesenchymal cell phenotypes, where lung …

[HTML][HTML] Increased AGE-RAGE ratio in idiopathic pulmonary fibrosis

C Machahua, A Montes-Worboys, R Llatjos… - Respiratory …, 2016 - Springer
Background The abnormal epithelial-mesenchymal restorative capacity in idiopathic pulmonary
fibrosis (IPF) has been recently associated with an accelerated aging process as a key …

[HTML][HTML] Serum AGE/RAGEs as potential biomarker in idiopathic pulmonary fibrosis

C Machahua, A Montes-Worboys… - Respiratory …, 2018 - Springer
Background The soluble receptor for advanced glycation end-products (sRAGE) has been
suggested that it acts as a decoy for capturing advanced glycation end-products (AGEs) and …

Predictive factors and prognostic effect of telomere shortening in pulmonary fibrosis

…, I Buendia‐Roldán, A MontesWorboys… - …, 2019 - Wiley Online Library
Background and objective The abnormal shortening of telomeres is a mechanism linking
ageing to idiopathic pulmonary fibrosis (IPF) that could be useful in the clinical setting. The …

[HTML][HTML] Lung transplant improves survival and quality of life regardless of telomere dysfunction

…, C Berastegui, A Montes-Worboys… - Frontiers in …, 2021 - frontiersin.org
Introduction: Fibrotic interstitial lung diseases (ILDs) are the first indication for lung transplantation
(LT). Telomere dysfunction has been associated with poor post-transplant outcomes. …

[HTML][HTML] Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria

…, R Surolia, S Karki, J Zolak, A Montes-Worboys… - Laboratory …, 2012 - nature.com
Non-tuberculous mycobacterial (NTM) infections occur in both immunocompromised and
immunocompetent hosts and are an increasingly recognized cause of morbidity and mortality. …