… The ELISpot evidence base is comprised predominantly of studies using the Lalvani ELISpot
test, which has recently been developed into the T-SPOT.TB test (Oxford Immunotec; Oxford…

Objectives To determine whether BCG vaccination protects against Mycobacterium
tuberculosis infection as assessed by interferon γ release assays (IGRA) in children. Design …

Objectives To evaluate the effectiveness of available rapid diagnostic tests to identify tuberculosis
(TB) infection. Data sources Electronic databases were searched from 1975 to August …

The nature of the CD8 + T cells that underlie antiviral protective immunological memory in
vivo is unclear. We have characterized peptide-specific CD8 + T lymphocytes directly ex vivo …

There is no reliable means of detecting latent M. tuberculosis infection, and even in patients
with active tuberculosis, infection is often unconfirmed. We hypothesized that M. tuberculosis …

The role of T cells in mediating heterosubtypic protection against natural influenza illness in
humans is uncertain. The 2009 H1N1 pandemic (pH1N1) provided a unique natural …

Background Identification of individuals latently infected with Mycobacterium tuberculosis is
an important part of tuberculosis control. The current method, the tuberculin skin test (TST), …

Background The SARS-CoV-2 delta (B.1.617.2) variant is highly transmissible and spreading
globally, including in populations with high vaccination rates. We aimed to investigate …

Rationale: T-cell responses during tuberculosis (TB) help contain Mycobacterium tuberculosis
in vivo but also cause collateral damage to host tissues. Immune regulatory mechanisms …

Protective immunity to Mycobacterium tuberculosis is poorly understood, but mounting
evidence, at least in animal models, implicates major histocompatibility complex class I-restricted …