Background The late-onset cerebellar ataxias (LOCAs) have largely resisted molecular
diagnosis. Methods We sequenced the genomes of six persons with autosomal dominant LOCA …

Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurrent upper
airway obstruction during sleep resulting in intermittent hypoxemia and sleep fragmentation. …

Parkinson’s disease (PD) is a relentlessly progressive neurodegenerative disorder associated
with hallmark motor and nonmotor symptoms (NMS) such as sleep disturbances and …

Previous studies have shown greater atrophy in grey and white matter of various brain regions
in patients with Parkinson’s disease with mild cognitive impairment than in those without. …

Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder diagnosed on the basis
of motor symptoms, but that also includes cognitive and visuo-spatial deficits. Though PD is …

Importance The COVID-19 pandemic is the greatest global test of health leadership of our
generation. There is an urgent need to provide guidance for leaders at all levels during the …

There is increasing interest in the effects of sleep and sleep disturbances on the brain,
particularly in relation to aging and neurodegenerative processes. Parkinson disease (PD) is the …

… Anne-Louise Lafontaine reports receiving personal fees from AbbVie (advisory board), during
the conduct of the study. Janis Miyasaki reports receiving grants from the Patient Centered …

Although botulinum toxin A (BTX) has been licensed in Canada for treatment of various
movement disorders since 1990, few clinical studies regarding its long‐term efficacy and side …

… 1 , Joyce Gordon, Barbara Snelgrove, Ivy Lim-Carter, Edward Fon, Wayne Martin,
Marguerite Wieler, Oksana Suchowersky, Alex Rajput, Anne L Lafontaine, Jon Stoessl …