A number of biologically relevant O 4 ‐phospho‐L‐tyrosine‐containing peptides have been
synthesized by either the global phosphorylation of the side‐chain‐unprotected L‐tyrosine …

Structural modifications of the γ-secretase inhibitor, LY411575, led to a malonamide analogue
(S),(S)-1 with potent inhibitory activity in vitro, but disappointing activity in a mouse model …

Endothelin-1 (ET-1) is mitogenic and/or antiapoptotic in human cancers, and antagonists to
ET-1 receptors are under evaluation for cancer treatment. Inhibition of ET-1 activation by the …

Platelet activation is a link in the pathophysiology of diseases prone to thrombosis and
inflammation. Numerous platelet markers, including mean platelet volume (MPV), have been …

The incorporation of O-phosphotyrosine into synthetic peptides using Fmoc-Tyr (PO 3 Me 2)-
OH in the Fmoc-polyamide procedure is described with the preparation of the model PT yr …

The platelet-to-lymphocyte ratio (PLR) has emerged as an informative marker revealing shifts
in platelet and lymphocyte counts due to acute inflammatory and prothrombotic states. PLR …

Review articles comprehensively covering a specific topic are crucial for successful research
and academic projects. Most editors consider review articles for special and regular issues …

The phosphorylated derivative Na-(tert-butoxycarbonyl)-0-(dimethylphosphono) tyrosine
anthraquinon-2-ylmethyl ester, Boc-Tyr (P03Me2)-OMaq (2), was prepared in high yields by …

A transient transfection process was established using a novel 'in-house' developed transfection
reagent, Ro-1539. It allows rapid production of large quantities of various recombinant …

A hydroxamic acid screening hit 1 was elaborated to 5,5-dimethyl-2-oxoazepane derivatives
exhibiting low nanomolar inhibition of γ-secretase, a key proteolytic enzyme involved in …