User profiles for A. Haromy
 | Alois HaromyUniversity of Alberta Verified email at ualberta.ca Cited by 9956 |
Metabolic modulation of glioblastoma with dichloroacetate
…, P Dromparis, L Webster, A Haromy… - Science translational …, 2010 - science.org
Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme,
develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative …
develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative …
An abnormal mitochondrial–hypoxia inducible factor-1α–Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded …
Background— The cause of pulmonary arterial hypertension (PAH) was investigated in humans
and fawn hooded rats (FHR), a spontaneously pulmonary hypertensive strain. Methods …
and fawn hooded rats (FHR), a spontaneously pulmonary hypertensive strain. Methods …
Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury …
…, F Eaton, K Hashimoto, G Harry, A Haromy… - Circulation, 2005 - Am Heart Assoc
Background— Bronchopulmonary dysplasia (BPD) and pulmonary emphysema, both
significant global health problems, are characterized by a loss of alveoli. Vascular endothelial …
significant global health problems, are characterized by a loss of alveoli. Vascular endothelial …
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
The pulmonary arteries (PA) in pulmonary arterial hypertension (PAH) are constricted and
remodeled;. They have suppressed apoptosis, partly attributable to suppression of the bone …
remodeled;. They have suppressed apoptosis, partly attributable to suppression of the bone …
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
Background— Sildenafil was recently approved for the treatment of pulmonary arterial
hypertension. The beneficial effects of phosphodiesterase type 5 (PDE5) inhibitors in pulmonary …
hypertension. The beneficial effects of phosphodiesterase type 5 (PDE5) inhibitors in pulmonary …
Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats
…, GJ Rey-Parra, J Galipeau, A Haromy… - American journal of …, 2009 - atsjournals.org
Rationale: Bronchopulmonary dysplasia (BPD) and emphysema are characterized by arrested
alveolar development or loss of alveoli; both are significant global health problems and …
alveolar development or loss of alveoli; both are significant global health problems and …
[HTML][HTML] Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is characterized by genetic and acquired abnormalities
that suppress apoptosis and enhance cell proliferation in the vascular wall, including …
that suppress apoptosis and enhance cell proliferation in the vascular wall, including …
The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted
In pulmonary arterial hypertension (PAH), antiapoptotic, proliferative, and inflammatory
diatheses converge to create an obstructive vasculopathy. A selective down-regulation of the Kv …
diatheses converge to create an obstructive vasculopathy. A selective down-regulation of the Kv …
Diversity in mitochondrial function explains differences in vascular oxygen sensing
…, V Hampl, A Nsair, XC Wu, G Harry, A Haromy… - Circulation …, 2002 - Am Heart Assoc
Renal arteries (RAs) dilate in response to hypoxia, whereas the pulmonary arteries (PAs)
constrict. In the PA, O 2 tension is detected by an unidentified redox sensor, which controls K + …
constrict. In the PA, O 2 tension is detected by an unidentified redox sensor, which controls K + …
[HTML][HTML] A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance
and be therapeutically targeted. Compared to normal cells, several human cancers have …
and be therapeutically targeted. Compared to normal cells, several human cancers have …