The flavonoid quercetin is metabolized into isorhamnetin, tamarixetin, and kaempferol, the
vascular effects of which are unknown. In the present study, the effects of quercetin and its …

In recent years, it has become evident that reactive oxygen species (ROS) play a critical role
in the regulation of several physiological and pathophysiological processes. Herein we …

In addition to playing a role as a structural component of cellular membranes, ceramide is
now clearly recognized as a bioactive lipid implicated in a variety of physiological functions. …

Pulmonary vasoconstriction is believed to be an early component of pulmonary arterial
hypertension. Intracellular calcium concentration ([Ca 2+ ] i ) is a major trigger for pulmonary …

All metazoans depend on the consumption of O 2 by the mitochondrial oxidative phosphorylation
system (OXPHOS) to produce energy. In addition, the OXPHOS uses O 2 to produce …

Multiple lines of evidence indicate that serotonin (5-hydroxytryptamine [5-HT]) and voltage-gated
K + (K V ) channels play a central role in the pathogenesis of pulmonary hypertension (…

Voltage-gated K + channels (K V ) and thromboxane A 2 (TXA 2 ) play critical roles in
controlling pulmonary arterial tone under physiological and pathological conditions. We …

Objective: Large conductance Ca 2+ -activated K + channels (BKCa) regulate coronary
artery tone in vivo, play a key role in blood pressure regulation, and have been suggested as …

The dietary flavonoid quercetin reduces blood pressure and improves endothelial function in
several rat models of hypertension. We analyzed the effects of quercetin and its methylated …

Epidemiological studies have reported an inverse association between dietary flavonoid intake
and mortality for ischemic heart disease. Quercetin reduces blood pressure and restores …