[HTML][HTML] Judging a plethora of p-values: how to contend with the problem of multiple testing-part 10 of a series on evaluation of scientific publications
A Victor, A Elsäßer, G Hommel… - Deutsches Arzteblatt …, 2010 - ncbi.nlm.nih.gov
Background When reading reports of medical research findings, one is usually confronted
with p-values. Publications typically contain not just one p-value, but an abundance of them, …
with p-values. Publications typically contain not just one p-value, but an abundance of them, …
Safety of empagliflozin in patients with type 2 diabetes and chronic kidney disease: pooled analysis of placebo-controlled clinical trials
…, T Kadowaki, R Agarwal, SJ Hauske, A Elsäßer… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE To assess the safety of empagliflozin in patients with type 2 diabetes and
moderate to severe chronic kidney disease (CKD) (category G3–4) enrolled in clinical trials. …
moderate to severe chronic kidney disease (CKD) (category G3–4) enrolled in clinical trials. …
[HTML][HTML] Pragmatic randomized clinical trials: best practices and statistical guidance
V Gamerman, T Cai, A Elsäßer - Health Services and Outcomes Research …, 2019 - Springer
Randomized clinical trials often serve the purpose of assessing the efficacy and safety of a
compound. By combining real-world evidence and randomization, pragmatic randomized …
compound. By combining real-world evidence and randomization, pragmatic randomized …
[HTML][HTML] Adaptive clinical trial designs for European marketing authorization: a survey of scientific advice letters from the European Medicines Agency
A Elsäßer, J Regnstrom, T Vetter, F Koenig… - Trials, 2014 - Springer
Background Since the first methodological publications on adaptive study design approaches
in the 1990s, the application of these approaches in drug development has raised …
in the 1990s, the application of these approaches in drug development has raised …
Humoral immune responses of lung cancer patients against the Transmembrane Phosphatase with TEnsin homology (TPTE)
…, A Breitkreuz, J Röhlig, U Luxemburger, A Elsäßer… - Lung Cancer, 2015 - Elsevier
Objective The cancer/testis (C/T) antigen Transmembrane Phosphatase with TEnsin homology
(TPTE) is aberrantly expressed in many tumors including lung cancer. In the present study…
(TPTE) is aberrantly expressed in many tumors including lung cancer. In the present study…
Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in borderline personality disorder
A Tadić, A Elsäßer, A Victor, R von Cube… - Journal of neural …, 2009 - Springer
The purpose of this study was to test for association between Borderline personality disorder
(BPD) and variants of the HTR1B and the brain-derived neurotrophic factor (BDNF) gene. …
(BPD) and variants of the HTR1B and the brain-derived neurotrophic factor (BDNF) gene. …
Impact of several histopathological prognosticators and local tumour extension on oncological outcome in pT3b/c N0M0 renal cell carcinoma
FC Roos, J Weirich, A Victor, A Elsäßer… - BJU …, 2009 - Wiley Online Library
OBJECTIVE To investigate the prognostic relevance of different histopathological features
and local tumour extension in patients with pT3b/c N0M0 renal cell carcinoma (RCC), as …
and local tumour extension in patients with pT3b/c N0M0 renal cell carcinoma (RCC), as …
[HTML][HTML] The adverse events and hemodynamic effects of adenosine-based cardiac MRI
…, A Schmermund, P Bramlage, A Elsässer… - Korean journal of …, 2011 - ncbi.nlm.nih.gov
Objective We wanted to prospectively assess the adverse events and hemodynamic effects
associated with an intravenous adenosine infusion in patients with suspected or known …
associated with an intravenous adenosine infusion in patients with suspected or known …
Comparison of prognostic usefulness (three years) of computed tomographic angiography versus 64-slice computed tomographic calcium scanner in subjects without …
A Schmermund, A Elsäßer, M Behl, A Magedanz… - The American journal of …, 2010 - Elsevier
Coronary computerized tomographic angiography (CTA) has been used as a noninvasive
method for ruling out high-grade stenoses. Even in the absence of such stenoses, analysis of …
method for ruling out high-grade stenoses. Even in the absence of such stenoses, analysis of …
Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder
A Tadić, A Elsässer, N Storm, U Baade… - The world journal of …, 2010 - Taylor & Francis
objectives. For patients with borderline personality disorder (BPD), we previously reported
an independent effect of the catechol-o-methyl-transferase (COMT) low-activity (Met 158 ) …
an independent effect of the catechol-o-methyl-transferase (COMT) low-activity (Met 158 ) …