[HTML][HTML] Judging a plethora of p-values: how to contend with the problem of multiple testing-part 10 of a series on evaluation of scientific publications

A Victor, A Elsäßer, G Hommel… - Deutsches Arzteblatt …, 2010 - ncbi.nlm.nih.gov
Background When reading reports of medical research findings, one is usually confronted
with p-values. Publications typically contain not just one p-value, but an abundance of them, …

Safety of empagliflozin in patients with type 2 diabetes and chronic kidney disease: pooled analysis of placebo-controlled clinical trials

…, T Kadowaki, R Agarwal, SJ Hauske, A Elsäßer… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE To assess the safety of empagliflozin in patients with type 2 diabetes and
moderate to severe chronic kidney disease (CKD) (category G3–4) enrolled in clinical trials. …

[HTML][HTML] Pragmatic randomized clinical trials: best practices and statistical guidance

V Gamerman, T Cai, A Elsäßer - Health Services and Outcomes Research …, 2019 - Springer
Randomized clinical trials often serve the purpose of assessing the efficacy and safety of a
compound. By combining real-world evidence and randomization, pragmatic randomized …

[HTML][HTML] Adaptive clinical trial designs for European marketing authorization: a survey of scientific advice letters from the European Medicines Agency

A Elsäßer, J Regnstrom, T Vetter, F Koenig… - Trials, 2014 - Springer
Background Since the first methodological publications on adaptive study design approaches
in the 1990s, the application of these approaches in drug development has raised …

Humoral immune responses of lung cancer patients against the Transmembrane Phosphatase with TEnsin homology (TPTE)

…, A Breitkreuz, J Röhlig, U Luxemburger, A Elsäßer… - Lung Cancer, 2015 - Elsevier
Objective The cancer/testis (C/T) antigen Transmembrane Phosphatase with TEnsin homology
(TPTE) is aberrantly expressed in many tumors including lung cancer. In the present study…

Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in borderline personality disorder

A Tadić, A Elsäßer, A Victor, R von Cube… - Journal of neural …, 2009 - Springer
The purpose of this study was to test for association between Borderline personality disorder
(BPD) and variants of the HTR1B and the brain-derived neurotrophic factor (BDNF) gene. …

Impact of several histopathological prognosticators and local tumour extension on oncological outcome in pT3b/c N0M0 renal cell carcinoma

FC Roos, J Weirich, A Victor, A Elsäßer… - BJU …, 2009 - Wiley Online Library
OBJECTIVE To investigate the prognostic relevance of different histopathological features
and local tumour extension in patients with pT3b/c N0M0 renal cell carcinoma (RCC), as …

[HTML][HTML] The adverse events and hemodynamic effects of adenosine-based cardiac MRI

…, A Schmermund, P Bramlage, A Elsässer… - Korean journal of …, 2011 - ncbi.nlm.nih.gov
Objective We wanted to prospectively assess the adverse events and hemodynamic effects
associated with an intravenous adenosine infusion in patients with suspected or known …

Comparison of prognostic usefulness (three years) of computed tomographic angiography versus 64-slice computed tomographic calcium scanner in subjects without …

A Schmermund, A Elsäßer, M Behl, A Magedanz… - The American journal of …, 2010 - Elsevier
Coronary computerized tomographic angiography (CTA) has been used as a noninvasive
method for ruling out high-grade stenoses. Even in the absence of such stenoses, analysis of …

Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder

A Tadić, A Elsässer, N Storm, U Baade… - The world journal of …, 2010 - Taylor & Francis
objectives. For patients with borderline personality disorder (BPD), we previously reported
an independent effect of the catechol-o-methyl-transferase (COMT) low-activity (Met 158 ) …