Combined pituitary hormone deficiency (CPHD) has an incidence of approximately 1 in
8000 births. Although the proportion of familial CPHD cases is unknown, about 10% have an …

BackgroundBicuspid aortic valve is the most common CHD. Its association with early valvular
dysfunction, endocarditis, thoracic aorta dilatation, and aortic dissection is well established.…

Introduction. Pulmonary arterial hypertension (PAH) is a rare disease that must be managed
in specialized centers; therefore, the availability of epidemiological national data is critical. …

Filled skutterudites R x Co 4 Sb 12 are excellent n-type thermoelectric materials owing to
their high electronic mobility and high effective mass, combined with low thermal conductivity …

objective To determine the spectrum of MEN1 mutations in Portuguese kindreds, and identify
mutation‐carriers. patients, design and results Six unrelated MEN1 families were studied …

The accurate prediction of the electronic properties of materials at a low computational
expense is a necessary condition for the development of effective high-throughput quantum-…

The benefits of patent foramen ovale (PFO) closure for cryptogenic stroke secondary prevention
are still debated. The Risk of Paradoxical Embolism (RoPE) study developed a score to …

The domestication of wild vicuña and guanaco by early pre-Inca cultures is an iconic example
of wildlife management and domestication in the Americas. Although domestic llamas and …

m-Calpain is a protease implicated in the control of cell adhesion through focal adhesion
disassembly. The mechanism by which the enzyme is spatially and temporally controlled is not …

Objective Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD),
which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, …