Target identification is the first step in the drug and vaccine discovery process; in silico
subtractive genomics is widely used in this process. Using this approach, in recent years, a large …

The neurotrophin brain-derived neurotrophic factor (BDNF) plays a key role in synaptic
plasticity, in part due to changes in local protein synthesis. Activation of TrkB (tropomyosin-…

Autism Spectrum Disorders are a heterogeneous group of neurodevelopmental disorders,
with rising incidence but little effective therapeutic intervention available. Currently two main …

In November 2004, a regional climate change workshop was held in Guatemala with the
goal of analyzing how climate extremes had changed in the region. Scientists from Central …

Importance Intravenous fluids are used for almost all intensive care unit (ICU) patients.
Clinical and laboratory studies have questioned whether specific fluid types result in improved …

Fisheries and aquaculture production, imports, exports and equitability of distribution
determine the supply of aquatic food to people. Aquatic food security is achieved when a food …

… The sampling area selected in this study was Santos Bay (São Paulo, Brazil), which receives
over 7367 m 3 of sewage per day. The main pollution sources of this coastal zone include …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS)
caused by demyelination, immune cell infiltration, and axonal damage. Herein, we sought …

Single-nucleotide polymorphisms within the genes coding for tumor necrosis factor (TNF)–α
and interleukin (IL)–10 have been associated with several infectious diseases. To determine …

Immune mediators associated with human tuberculosis (TB) remain poorly defined. This
study quantified levels of lung immune mediator gene expression at the time of diagnosis and …