Endocytic pathways regulate Toll‐like receptor 4 signaling and link innate and adaptive immunity
…, H Stenmark, G Tunheim, Ø Sandanger… - The EMBO …, 2006 - embopress.org
Immune responses are initiated when molecules of microbial origin are sensed by the Toll‐like
receptors (TLRs). We now report the identification of essential molecular components for …
receptors (TLRs). We now report the identification of essential molecular components for …
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury
Ø Sandanger, T Ranheim, LE Vinge… - Cardiovascular …, 2013 - academic.oup.com
Aims Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3)
is considered necessary for initiating a profound sterile inflammatory response. NLRP3 …
is considered necessary for initiating a profound sterile inflammatory response. NLRP3 …
Effect of therapeutic drug monitoring vs standard therapy during maintenance infliximab therapy on disease control in patients with immune-mediated inflammatory …
…, KK Jørgensen, GL Goll, MK Brun, Ø Sandanger… - Jama, 2021 - jamanetwork.com
Importance Proactive therapeutic drug monitoring (TDM), consisting of individualized
treatment based on scheduled assessments of serum drug levels, has been proposed as an …
treatment based on scheduled assessments of serum drug levels, has been proposed as an …
Effect of therapeutic drug monitoring vs standard therapy during infliximab induction on disease remission in patients with chronic immune-mediated inflammatory …
Importance Proactive therapeutic drug monitoring (TDM), defined as individualized drug
dosing based on scheduled monitoring of serum drug levels, has been proposed as an …
dosing based on scheduled monitoring of serum drug levels, has been proposed as an …
Targeting the inflammasome in cardiovascular disease
MB Olsen, I Gregersen, Ø Sandanger, K Yang… - Basic to Translational …, 2022 - jacc.org
The pathogenesis of cardiovascular disease (CVD) is complex and multifactorial, and
inflammation plays a central role. Inflammasomes are multimeric protein complexes that are …
inflammation plays a central role. Inflammasomes are multimeric protein complexes that are …
Increased interleukin‐1β levels are associated with left ventricular hypertrophy and remodelling following acute st segment elevation myocardial infarction treated by …
…, T Ueland, C Manhenke, Ø Sandanger… - Journal of internal …, 2012 - Wiley Online Library
Ørn S, Ueland T, Manhenke C, Sandanger Ø, Godang K, Yndestad A, Mollnes TE, Dickstein
K, Aukrust P (Stavanger University Hospital, Stavanger; Oslo University Hospital …
K, Aukrust P (Stavanger University Hospital, Stavanger; Oslo University Hospital …
NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective
Ø Sandanger, E Gao, T Ranheim, M Bliksøen… - Biochemical and …, 2016 - Elsevier
Background The innate immune receptor NLRP3 recognizes tissue damage and initiates
inflammatory processes through formation multiprotein complexes with the adaptor protein …
inflammatory processes through formation multiprotein complexes with the adaptor protein …
[HTML][HTML] Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
…, SS Bakke, I Gregersen, S Holm, Ø Sandanger… - …, 2020 - thelancet.com
Background During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in
the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD …
the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD …
[HTML][HTML] Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice
…, A Barratt-Due, SE Pischke, Ø Sandanger… - The Journal of …, 2014 - journals.aai.org
Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are
associated with high morbidity and mortality. The complement system and TLRs provide …
associated with high morbidity and mortality. The complement system and TLRs provide …
Cellular sources and inducers of cytokines present in acute wound fluid
Ø Grimstad, Ø Sandanger, L Ryan… - Wound repair and …, 2011 - Wiley Online Library
Acute wounds contain many biological active molecules, including several cytokines and
growth factors. However, the cellular sources of each molecule, as well as the stimuli inducing …
growth factors. However, the cellular sources of each molecule, as well as the stimuli inducing …