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Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain.
Odolczyk N, Fritsch J, Norez C, Servel N, da Cunha MF, Bitam S, Kupniewska A, Wiszniewski L, Colas J, Tarnowski K, Tondelier D, Roldan A, Saussereau EL, Melin-Heschel P, Wieczorek G, Lukacs GL, Dadlez M, Faure G, Herrmann H, Ollero M, Becq F, Zielenkiewicz P, Edelman A. Odolczyk N, et al. Among authors: melin heschel p. EMBO Mol Med. 2013 Oct;5(10):1484-501. doi: 10.1002/emmm.201302699. Epub 2013 Aug 27. EMBO Mol Med. 2013. PMID: 23982976 Free PMC article.
Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a.
Bertrand J, Boucherle B, Billet A, Melin-Heschel P, Dannhoffer L, Vandebrouck C, Jayle C, Routaboul C, Molina MC, Décout JL, Becq F, Norez C. Bertrand J, et al. Among authors: melin heschel p. Eur Respir J. 2010 Aug;36(2):311-22. doi: 10.1183/09031936.00122509. Epub 2010 Jan 28. Eur Respir J. 2010. PMID: 20110398 Free article.