Case report of delayed seroprotection rather than non-response after primary three-dose hepatitis B vaccination

Özgür M Koc; Jan Damoiseaux; Inge H M van Loo; Heloise I L Masquillier; Astrid M L Oude Lashof

doi:10.1016/j.vaccine.2019.10.022

Case report of delayed seroprotection rather than non-response after primary three-dose hepatitis B vaccination

Vaccine. 2020 Jan 10;38(2):112-114. doi: 10.1016/j.vaccine.2019.10.022. Epub 2019 Oct 21.

Authors

Özgür M Koc¹, Jan Damoiseaux², Inge H M van Loo³, Heloise I L Masquillier⁴, Astrid M L Oude Lashof⁵

Affiliations

¹ Department of Medical Microbiology, School of NUTRIM, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands; Department of Gastro-Enterology and Hepatology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600 Genk, Belgium; Faculty of Medicine and Life Sciences, Hasselt University, Martelarenlaan 42, 3500 Hasselt, Belgium. Electronic address: o.koc@mumc.nl.
² Central Diagnostic Laboratory, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands. Electronic address: jan.damoiseaux@mumc.nl.
³ Department of Medical Microbiology, School of CAPHRI, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands. Electronic address: ihm.van.loo@mumc.nl.
⁴ Department of Hematology, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ, Maastricht, the Netherlands. Electronic address: heloise.masquillier@mumc.nl.
⁵ Department of Medical Microbiology, School of NUTRIM, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands. Electronic address: a.oudelashof@mumc.nl.

PMID: 31648909
DOI: 10.1016/j.vaccine.2019.10.022

Abstract

We describe a delayed hepatitis B seroprotection 12 weeks after the primary vaccination schedule in a 57-year-old male with smoldering multiple myeloma. Based on undetectable anti-HBs antibodies 6 weeks after the third vaccination, the index person was previously considered to be a hepatitis B vaccine non-responder. Because hepatitis B vaccination started in the 1980s, many hepatitis B vaccine non-responders have received a revaccination regimen. If more cases of genuine delayed hepatitis B seroprotection surface in patients with hematologic malignancies, delayed seroprotection should be considered before the commencement of hepatitis B revaccination.

Keywords: Delayed seroprotection; Hepatitis B; Humoral Immunity; Non-responder; Vaccine.

Publication types

Case Reports

MeSH terms

Hepatitis B / immunology
Hepatitis B / prevention & control*
Hepatitis B Antibodies / immunology
Hepatitis B Vaccines / administration & dosage*
Hepatitis B Vaccines / immunology
Humans
Immunization, Secondary
Male
Middle Aged
Multiple Myeloma / pathology
Time Factors
Vaccination / methods*

Substances

Hepatitis B Antibodies
Hepatitis B Vaccines