Clinical Significance of Circulating Osteopontin Levels in Patients With Lung Cancer and Correlation With VEGF and MMP-9

Cancer Invest. 2016 Sep 13;34(8):385-92. doi: 10.1080/07357907.2016.1223301. Epub 2016 Sep 13.

Abstract

Osteopontin (OPN) is a multifunctional cytokine involved in carcinogenesis. Serum levels of OPN, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-9 (MMP-9) were measured by ELISA in 90 lung cancer patients. OPN levels were elevated in patients compared to controls (p <.0001). Smokers, patients with worse performance status, and weight loss exhibited higher OPN levels (p =.0012,.00036, and.0003, respectively). Increased OPN levels were associated with worse survival (p =.0018). Finally, OPN levels were positively correlated with both VEGF (p =.0008) and MMP-9 (p <.0001). OPN might serve as a prognostic biomarker, and the positive correlation between OPN and both VEGF and MMP-9 could implicate new insights in tumor angiogenesis.

Keywords: Prognostic studies; angiogenesis; cancer biomarkers; lung cancer.

MeSH terms

  • Aged
  • Biomarkers, Tumor*
  • Biopsy
  • Case-Control Studies
  • Female
  • Humans
  • Lung Neoplasms / blood*
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / mortality
  • Male
  • Matrix Metalloproteinase 9 / blood*
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Staging
  • Neovascularization, Pathologic
  • Osteopontin / blood*
  • Prognosis
  • Vascular Endothelial Growth Factor A / blood*

Substances

  • Biomarkers, Tumor
  • Vascular Endothelial Growth Factor A
  • Osteopontin
  • Matrix Metalloproteinase 9