Abstract
Recent findings have significantly advanced our understanding of the mechanism by which the potent immunosuppressive drug rapamycin inhibits cytokine-dependent lymphocyte proliferation. The protein targeted by the immunophilin-rapamycin complex is a member of a newly defined family of phosphoinositide-3-kinase-related kinases. The rapamycin target protein functions as a protein kinase in a signal transduction pathway that regulates the synthesis of proteins required for cell-cycle progression in both lymphoid and nonlymphoid cells.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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3-Phosphoinositide-Dependent Protein Kinases
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Adaptor Proteins, Signal Transducing
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Animals
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Carrier Proteins / drug effects*
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Carrier Proteins / physiology
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Cell Cycle Proteins / biosynthesis
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Cell Cycle Proteins / genetics
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Cell Survival
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DNA-Binding Proteins / drug effects*
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DNA-Binding Proteins / physiology
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Enzyme Activation
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Eukaryotic Initiation Factors
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Fungal Proteins / genetics
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Fungal Proteins / physiology
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Gene Expression Regulation / physiology
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Growth Substances / physiology
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Heat-Shock Proteins / drug effects*
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Heat-Shock Proteins / physiology
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Immunosuppressive Agents / pharmacology*
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Mice
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Models, Immunological
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Multigene Family
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Phosphatidylinositol 3-Kinases*
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Phosphoproteins / metabolism
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Phosphotransferases (Alcohol Group Acceptor) / genetics
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Phosphotransferases (Alcohol Group Acceptor) / physiology
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Polyenes / pharmacology*
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Protein Kinases*
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Protein Serine-Threonine Kinases / chemistry
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Saccharomyces cerevisiae / drug effects
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae Proteins*
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Signal Transduction / physiology*
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Sirolimus
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TOR Serine-Threonine Kinases
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Tacrolimus / pharmacology
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Tacrolimus Binding Proteins
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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Cell Cycle Proteins
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DNA-Binding Proteins
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EIF4EBP1 protein, human
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Eif4ebp1 protein, mouse
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Eukaryotic Initiation Factors
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Fungal Proteins
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Growth Substances
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Heat-Shock Proteins
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Immunosuppressive Agents
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Phosphoproteins
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Polyenes
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Saccharomyces cerevisiae Proteins
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Protein Kinases
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Phosphotransferases (Alcohol Group Acceptor)
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MTOR protein, human
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mTOR protein, mouse
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TOR1 protein, S cerevisiae
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TOR2 protein, S cerevisiae
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3-Phosphoinositide-Dependent Protein Kinases
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Protein Serine-Threonine Kinases
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TOR Serine-Threonine Kinases
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Tacrolimus Binding Proteins
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Sirolimus
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Tacrolimus