Treatment of progressive rheumatoid interstitial lung disease with cyclosporine

J Rheumatol. 1995 Nov;22(11):2163-5.

Abstract

A 62-year-old man with longstanding rheumatoid arthritis (RA) presented with dyspnea. Active rheumatoid interstitial lung disease was documented by high resolution computed tomography, gallium scan, and bronchoalveolar lavage. He responded to high dose prednisone, but had unacceptable side effects. Chlorambucil and cyclophosphamide were not steroid sparing. After starting cyclosporine 3 mg/kg/day he was able to stop prednisone and his symptoms improved and stabilized. Pulmonary function showed sustained improvement during 2 years of followup. His RA has been well controlled. Side effects have been mild hypertension and increased serum creatinine.

Publication types

  • Case Reports

MeSH terms

  • Arthritis, Rheumatoid / complications*
  • Cyclosporine / therapeutic use*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Lung / drug effects
  • Lung / physiopathology
  • Male
  • Middle Aged
  • Pulmonary Fibrosis / diagnostic imaging
  • Pulmonary Fibrosis / drug therapy*
  • Pulmonary Fibrosis / etiology
  • Radiography, Thoracic
  • Tomography, X-Ray Computed

Substances

  • Immunosuppressive Agents
  • Cyclosporine