Abstract
The beta effects of adrenergic stimulation are often diminished in asthmatics in whom the condition is active. Corticosteroids are thought to lower the threshold of beta-adrenergic receptors to the response of catecholamines. A single intravenous injection of 40 mg prednisolone appeared to restore responsiveness to inhaled isoprenaline in eight out of ten chronic asthmatics who were previously non-responsive to catecholamines.
MeSH terms
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Adult
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Aerosols
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Aged
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Asthma / drug therapy*
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Drug Synergism
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Drug Therapy, Combination
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Female
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Follow-Up Studies
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Humans
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Injections, Intravenous
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Isoproterenol / administration & dosage
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Isoproterenol / therapeutic use
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Male
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Middle Aged
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Placebos
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Prednisolone / administration & dosage*
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Prednisolone / pharmacology
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Prednisolone / therapeutic use
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Receptors, Adrenergic / drug effects*
Substances
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Aerosols
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Placebos
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Receptors, Adrenergic
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Prednisolone
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Isoproterenol