Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis

N Engl J Med. 2015 Nov 12;373(20):1986-8. doi: 10.1056/NEJMc1505196.

Abstract

Treatment of multidrug-resistant Mycobacterium tuberculosis is a challenge. This letter describes the emergence of resistance to new therapies, bedaquiline and delamanid.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antitubercular Agents / therapeutic use*
  • Diarylquinolines / therapeutic use*
  • Drug Resistance, Bacterial / genetics*
  • Drug Therapy, Combination
  • Humans
  • Male
  • Mutation*
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / genetics*
  • Nitroimidazoles / therapeutic use*
  • Oxazoles / therapeutic use*
  • Tuberculosis, Multidrug-Resistant / drug therapy*

Substances

  • Antitubercular Agents
  • Diarylquinolines
  • Nitroimidazoles
  • OPC-67683
  • Oxazoles
  • bedaquiline