Abstract
The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer (NSCLC). The common activation of ALK has led to the use of the ALK tyrosine kinase inhibitor (TKI) crizotinib in a range of patient populations and to the rapid development of second-generation drugs targeting ALK. In this Review, we discuss our current understanding of ALK function in human cancer and the implications for tumour treatment.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anaplastic Lymphoma Kinase
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Animals
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Antineoplastic Agents / therapeutic use
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Caenorhabditis elegans Proteins / physiology
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Cell Transformation, Neoplastic / genetics
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Clinical Trials as Topic
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Crizotinib
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Drosophila Proteins / physiology
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Drug Resistance, Neoplasm
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Enzyme Induction
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Gene Expression Regulation, Developmental
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Gene Expression Regulation, Neoplastic
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Humans
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Lymphoma, Large-Cell, Anaplastic / enzymology
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Lymphoma, Large-Cell, Anaplastic / genetics
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Mice
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Models, Biological
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Models, Molecular
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Mutation
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Neoplasm Proteins / biosynthesis
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Neoplasm Proteins / chemistry
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology*
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Neoplasms / drug therapy
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Neoplasms / enzymology*
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Neoplasms / genetics
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Oncogene Proteins, Fusion / genetics
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Oncogene Proteins, Fusion / physiology
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Protein Conformation
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Protein-Tyrosine Kinases / physiology
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Pyrazoles / therapeutic use
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Pyridines / therapeutic use
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Receptor Protein-Tyrosine Kinases / biosynthesis
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Receptor Protein-Tyrosine Kinases / chemistry
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Receptor Protein-Tyrosine Kinases / genetics
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Receptor Protein-Tyrosine Kinases / physiology*
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Signal Transduction
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Translocation, Genetic
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Zebrafish Proteins / physiology
Substances
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Antineoplastic Agents
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Caenorhabditis elegans Proteins
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Drosophila Proteins
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Neoplasm Proteins
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Oncogene Proteins, Fusion
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Pyrazoles
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Pyridines
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Zebrafish Proteins
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Crizotinib
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ALK protein, human
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Alk protein, mouse
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Anaplastic Lymphoma Kinase
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Protein-Tyrosine Kinases
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Receptor Protein-Tyrosine Kinases
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Scd-2 protein, C elegans