Abstract
Allergic asthma is an inflammatory disease of the airways in which epithelial cells, dendritic cells and innate lymphoid cells are increasingly implicated. Recent findings suggest that apoptotic cells are phagocytosed by airway epithelial cells in a Rac1-dependent manner and this leads to dampening of innate and adaptive immunity to allergens.
MeSH terms
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Allergens / immunology
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Apoptosis*
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Asthma / immunology
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Asthma / metabolism
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Asthma / pathology
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Dendritic Cells / immunology
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Dendritic Cells / physiology
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Epithelial Cells / cytology
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Epithelial Cells / metabolism*
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Humans
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Interleukin-10 / metabolism
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Interleukin-33
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Interleukins / antagonists & inhibitors
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Interleukins / metabolism
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Phagocytes / immunology
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Th2 Cells / immunology
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Transforming Growth Factor beta / metabolism
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rac1 GTP-Binding Protein / metabolism
Substances
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Allergens
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IL33 protein, human
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Interleukin-33
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Interleukins
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Transforming Growth Factor beta
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Interleukin-10
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rac1 GTP-Binding Protein