Abstract
Endometrial biopsies were performed during the luteal phase just before an IVF cycle in 104 infertile women, and immunohistochemical staining was performed to investigate expression patterns of hCG-LH receptor, leukemia-inhibitory factor, macrophage colony-stimulating factor, HOXA-10, vascular endothelial growth factor A, and their relation to subsequent IVF pregnancy. Only glandular expression of vascular endothelial growth factor A in early luteal endometrium was significantly higher in the pregnant group compared with the nonpregnant group (6.0 ± 3.9 vs. 2.9 ± 3.4) and thus could be a predicting marker for subsequent IVF pregnancy.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
MeSH terms
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Adult
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Biomarkers / analysis
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Biopsy
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Case-Control Studies
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Endometrium / chemistry*
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Endometrium / physiopathology
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Female
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Fertilization in Vitro*
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Homeobox A10 Proteins
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Homeodomain Proteins / analysis
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Humans
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Immunohistochemistry
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Infertility / metabolism
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Infertility / physiopathology
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Infertility / therapy*
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Leukemia Inhibitory Factor / analysis
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Luteal Phase / metabolism
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Macrophage Colony-Stimulating Factor / analysis
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Male
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Pregnancy
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Pregnancy Rate
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Receptors, LH / analysis
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Republic of Korea
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Treatment Outcome
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Up-Regulation
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Vascular Endothelial Growth Factor A / analysis*
Substances
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Biomarkers
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Homeobox A10 Proteins
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Homeodomain Proteins
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LIF protein, human
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Leukemia Inhibitory Factor
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Receptors, LH
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VEGFA protein, human
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Vascular Endothelial Growth Factor A
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HOXA10 protein, human
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Macrophage Colony-Stimulating Factor