Abstract
There has been an increase in our understanding of the complexity of the T cell response to mycobacterial infection recently. Improved tools have allowed the determination of the location and kinetics of naïve T cell activation in the mouse as well the variety of function of mycobacteria-specific cells in humans. There is also an increased appreciation of the balance required during mycobacterial infection between anti-bacterial activity and control of the immunopathologic response. The integration of the T cell functional data with the consequences of infection should improve rational vaccine design.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cytokines / immunology
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Humans
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Lung / immunology
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Lung / microbiology
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Lung / pathology
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Mice
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Mycobacterium tuberculosis / growth & development
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Mycobacterium tuberculosis / immunology*
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Mycobacterium tuberculosis / pathogenicity
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Phagocytes / immunology*
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Phagocytes / microbiology
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Phagocytes / pathology
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / microbiology
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T-Lymphocyte Subsets / pathology
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T-Lymphocytes, Regulatory / immunology*
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T-Lymphocytes, Regulatory / microbiology
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T-Lymphocytes, Regulatory / pathology
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Tuberculosis Vaccines / therapeutic use
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Tuberculosis, Pulmonary / immunology*
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Tuberculosis, Pulmonary / pathology
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Tuberculosis, Pulmonary / therapy
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Virulence
Substances
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Cytokines
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Tuberculosis Vaccines