Abstract
In this review, we aim to put in perspective the biology of a multifunctional leukocyte, the eosinophil, by placing it in the context of innate and adaptive immune responses. Eosinophils have a unique contribution in initiating inflammatory and adaptive responses, due to their bidirectional interactions with dendritic cells and T cells, as well as their large panel of secreted cytokines and soluble mediators. The mechanisms and consequences of eosinophil responses in experimental inflammatory models and human diseases are discussed.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigen Presentation / immunology
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Bacterial Infections / immunology*
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Bacterial Infections / metabolism
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Cell Adhesion Molecules / immunology
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Cell Adhesion Molecules / metabolism
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Cytokines / immunology*
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Cytokines / metabolism
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Eosinophil Cationic Protein / immunology
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Eosinophil Cationic Protein / metabolism
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Eosinophil Major Basic Protein / immunology
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Eosinophil Major Basic Protein / metabolism
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Eosinophil-Derived Neurotoxin / immunology
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Eosinophil-Derived Neurotoxin / metabolism
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Eosinophils / immunology*
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Eosinophils / physiology
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Humans
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Hypersensitivity / immunology*
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Hypersensitivity / metabolism
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Integrins / immunology
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Integrins / metabolism
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Lymphocyte Function-Associated Antigen-1 / immunology
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Lymphocyte Function-Associated Antigen-1 / metabolism
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Macrophage-1 Antigen / immunology
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Macrophage-1 Antigen / metabolism
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Mast Cells / immunology
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Mast Cells / metabolism
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Peroxidase / immunology
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Peroxidase / metabolism
Substances
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Cell Adhesion Molecules
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Cytokines
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Integrins
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Lymphocyte Function-Associated Antigen-1
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Macrophage-1 Antigen
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integrin alpha4beta7
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Peroxidase
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Eosinophil-Derived Neurotoxin
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Eosinophil Cationic Protein
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Eosinophil Major Basic Protein