Background: Infliximab, a tumor necrosis factor alpha antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports.
Objective: The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab.
Methods: Three patients with severe GPP were followed to assess the efficacy of long-term treatment with infliximab.
Results: Infliximab therapy was more efficacious with infusion every 6 to 8 weeks in combination with methotrexate.
Conclusion: Infliximab may be efficacious for some patients for the long-term management of GPP. Maintaining a strict infliximab infusion schedule and concomitant methotrexate therapy may decrease infusion reactions and increase efficacy.