Abstract
Interleukin-1 receptor antagonist (IL-1ra) has been shown to play a crucial role in the prevention of various inflammatory diseases. There is also convincing evidence that IL-1ra is able to counteract inflammatory effects of IL-1 members implicated in insulin resistance and diabetes. However, the use of knock-out animal models provides evidence to the contrary and the role of IL-1ra in obesity-linked anomalies remains controversial. This minireview gets an insight into recent findings on the implication of IL-1ra and its gene polymorphism in diabetes and obesity, discusses the potential dual effects of IL-1ra observed in different models, and comments on future directions.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Diabetes Mellitus / genetics
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Diabetes Mellitus / metabolism*
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Disease Models, Animal
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Humans
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Inflammation / immunology
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Inflammation / metabolism
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Inflammation / prevention & control
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Insulin Resistance* / genetics
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Interleukin 1 Receptor Antagonist Protein / genetics
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Interleukin 1 Receptor Antagonist Protein / metabolism*
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Interleukin 1 Receptor Antagonist Protein / therapeutic use
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Interleukin-1 / antagonists & inhibitors*
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Interleukin-1 / genetics
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Interleukin-1 / metabolism
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Mice
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Mice, Knockout
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Obesity / genetics
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Obesity / metabolism*
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Polymorphism, Genetic
Substances
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1