Abstract
To improve multidrug-resistant tuberculosis (MDR-TB) detection, we successfully introduced the rpoB gene mutation line probe assay into the national laboratory in Latvia, a country with epidemic MDR-TB. The assay detected rifampin resistance with 91% sensitivity and 96% specificity within 1 to 5 days (vs. 12-47 days for BACTEC).
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / pharmacology
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Humans
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Latvia / epidemiology
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Microbial Sensitivity Tests / methods
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / isolation & purification
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Sputum / microbiology
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Tuberculosis, Multidrug-Resistant / diagnosis
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Tuberculosis, Multidrug-Resistant / epidemiology
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Tuberculosis, Multidrug-Resistant / genetics*