Abstract
The range of regulatory T cell (T(R) cell) types that control immune responses is poorly understood. We describe here a population of T(R) cells that developed in vivo from naive CD4(+)CD25(-) T cells during a T helper type 1 (T(H)1)-polarized response, distinct from CD25(+) T(R) cells. These antigen-specific T(R) cells were induced by CD8alpha(+) DCs, produced both interleukin 10 and interferon-gamma, and potently inhibited the development of airway hyper-reactivity. These T(R) cells expressed the transcription factors Foxp3 and T-bet, indicating that these T(R) cells are related to T(H)1 cells. Thus, adaptive T(R) cells are heterogeneous and comprise T(H)1-like T(R) cells as well as previously described T(H)2-like T(R) cells, which express Foxp3 and are induced during the development of respiratory tolerance by CD8alpha(-) DCs.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Antigens, Differentiation, T-Lymphocyte / metabolism
-
CD8 Antigens / immunology
-
DNA-Binding Proteins / genetics*
-
DNA-Binding Proteins / immunology
-
DNA-Binding Proteins / metabolism
-
Dendritic Cells / immunology
-
Dendritic Cells / metabolism
-
Forkhead Transcription Factors
-
Inducible T-Cell Co-Stimulator Protein
-
Interferon-gamma / metabolism
-
Interleukin-10 / metabolism
-
Mice
-
Respiratory System / immunology*
-
T-Box Domain Proteins
-
Th1 Cells / immunology*
-
Th1 Cells / metabolism
-
Transcription Factors / metabolism
Substances
-
Antigens, Differentiation, T-Lymphocyte
-
CD8 Antigens
-
CD8alpha antigen
-
DNA-Binding Proteins
-
Forkhead Transcription Factors
-
Foxp3 protein, mouse
-
Icos protein, mouse
-
Inducible T-Cell Co-Stimulator Protein
-
T-Box Domain Proteins
-
T-box transcription factor TBX21
-
Transcription Factors
-
Interleukin-10
-
Interferon-gamma