Abstract
In a recent issue of Molecular Cell, Sabapathy et al. (2004) demonstrate that JNK2 destabilizes c-Jun under nonstimulating conditions, whereas after stress, activated JNK1 phosphorylates c-Jun, resulting in its activation and stabilization, thereby highlighting functional differences between JNK1 and JNK2.
Copyright 2004 Cell Press
MeSH terms
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Animals
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Cells, Cultured
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Enzyme Activation
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Fibroblasts / metabolism
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Mice
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Mice, Knockout
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Mitogen-Activated Protein Kinase 8
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Mitogen-Activated Protein Kinase 9
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Mitogen-Activated Protein Kinases / metabolism*
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Models, Biological
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Phosphorylation
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Proto-Oncogene Proteins c-jun / metabolism*
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Substrate Specificity
Substances
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Proto-Oncogene Proteins c-jun
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Mitogen-Activated Protein Kinase 9
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Mitogen-Activated Protein Kinase 8
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Mitogen-Activated Protein Kinases