JNKing Revealed

Mol Cell. 2004 Sep 24;15(6):843-4. doi: 10.1016/j.molcel.2004.09.011.

Abstract

In a recent issue of Molecular Cell, Sabapathy et al. (2004) demonstrate that JNK2 destabilizes c-Jun under nonstimulating conditions, whereas after stress, activated JNK1 phosphorylates c-Jun, resulting in its activation and stabilization, thereby highlighting functional differences between JNK1 and JNK2.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cells, Cultured
  • Enzyme Activation
  • Fibroblasts / metabolism
  • Mice
  • Mice, Knockout
  • Mitogen-Activated Protein Kinase 8
  • Mitogen-Activated Protein Kinase 9
  • Mitogen-Activated Protein Kinases / metabolism*
  • Models, Biological
  • Phosphorylation
  • Proto-Oncogene Proteins c-jun / metabolism*
  • Substrate Specificity

Substances

  • Proto-Oncogene Proteins c-jun
  • Mitogen-Activated Protein Kinase 9
  • Mitogen-Activated Protein Kinase 8
  • Mitogen-Activated Protein Kinases