Abstract
Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Anticarcinogenic Agents / pharmacology*
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Anticarcinogenic Agents / therapeutic use
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Calcium, Dietary / pharmacology*
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Calcium, Dietary / therapeutic use
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Colonic Neoplasms / etiology
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Colonic Neoplasms / prevention & control*
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Folic Acid / pharmacology*
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Folic Acid / therapeutic use
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Gene Expression Regulation
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Humans
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Mice
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Models, Biological
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Signal Transduction
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Vitamin D / pharmacology*
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Vitamin D / therapeutic use
Substances
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Anticarcinogenic Agents
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Calcium, Dietary
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Vitamin D
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Folic Acid