Abstract
Elucidation of the biochemistry of leukotriene production and the pharmacology of its actions has led to the development of a number of therapeutic agents shown to be of value in the treatment of asthma. These agents either prevent the synthesis of the leukotrienes, by preventing the action of the 5-lipoxygenase-activating protein or the catalytic action of the 5-lipoxygenase, or by inhibiting the action of leukotrienes at the CysLT1 receptor. Numerous clinical trials in exercise-induced asthma, allergen-induced asthma, aspirin-induced asthma, and spontaneously occurring asthmatic episodes have indicated that these agents are safe and effective asthma treatments.
MeSH terms
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Acetates / pharmacology
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Acetates / therapeutic use
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Allergens / adverse effects
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Anti-Asthmatic Agents / classification
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Anti-Asthmatic Agents / pharmacology
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Anti-Asthmatic Agents / therapeutic use*
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Arachidonate 5-Lipoxygenase / physiology
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Arachidonic Acid / metabolism
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Aspirin / adverse effects
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Asthma / drug therapy*
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Asthma / etiology
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Asthma / metabolism
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Asthma, Exercise-Induced / drug therapy
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Asthma, Exercise-Induced / metabolism
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Bronchoconstriction / drug effects
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Chromones / pharmacology
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Chromones / therapeutic use
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Clinical Trials as Topic
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Cyclopropanes
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Double-Blind Method
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Humans
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Hydroxyurea / analogs & derivatives
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Hydroxyurea / pharmacology
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Hydroxyurea / therapeutic use
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Indoles
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Leukotriene Antagonists* / pharmacology
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Leukotriene Antagonists* / therapeutic use*
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Leukotrienes / biosynthesis*
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Lipoxygenase Inhibitors / pharmacology
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Lipoxygenase Inhibitors / therapeutic use*
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Membrane Lipids / metabolism
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Membrane Proteins*
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Phenylcarbamates
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Phospholipases A / metabolism
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Quinolines / pharmacology
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Quinolines / therapeutic use
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Randomized Controlled Trials as Topic
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Receptors, Leukotriene*
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Safety
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Sulfides
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Sulfonamides
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Tosyl Compounds / pharmacology
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Tosyl Compounds / therapeutic use
Substances
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Acetates
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Allergens
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Anti-Asthmatic Agents
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Chromones
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Cyclopropanes
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Indoles
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Leukotriene Antagonists
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Leukotrienes
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Lipoxygenase Inhibitors
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Membrane Lipids
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Membrane Proteins
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Phenylcarbamates
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Quinolines
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Receptors, Leukotriene
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Sulfides
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Sulfonamides
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Tosyl Compounds
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Arachidonic Acid
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cysteinyl leukotriene receptor 2
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Arachidonate 5-Lipoxygenase
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Phospholipases A
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leukotriene D4 receptor
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montelukast
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Aspirin
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pranlukast
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zileuton
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Hydroxyurea
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zafirlukast