Asthma therapy with agents preventing leukotriene synthesis or action

Proc Assoc Am Physicians. 1999 Nov-Dec;111(6):547-59. doi: 10.1046/j.1525-1381.1999.t01-1-99242.x.

Abstract

Elucidation of the biochemistry of leukotriene production and the pharmacology of its actions has led to the development of a number of therapeutic agents shown to be of value in the treatment of asthma. These agents either prevent the synthesis of the leukotrienes, by preventing the action of the 5-lipoxygenase-activating protein or the catalytic action of the 5-lipoxygenase, or by inhibiting the action of leukotrienes at the CysLT1 receptor. Numerous clinical trials in exercise-induced asthma, allergen-induced asthma, aspirin-induced asthma, and spontaneously occurring asthmatic episodes have indicated that these agents are safe and effective asthma treatments.

Publication types

  • Review

MeSH terms

  • Acetates / pharmacology
  • Acetates / therapeutic use
  • Allergens / adverse effects
  • Anti-Asthmatic Agents / classification
  • Anti-Asthmatic Agents / pharmacology
  • Anti-Asthmatic Agents / therapeutic use*
  • Arachidonate 5-Lipoxygenase / physiology
  • Arachidonic Acid / metabolism
  • Aspirin / adverse effects
  • Asthma / drug therapy*
  • Asthma / etiology
  • Asthma / metabolism
  • Asthma, Exercise-Induced / drug therapy
  • Asthma, Exercise-Induced / metabolism
  • Bronchoconstriction / drug effects
  • Chromones / pharmacology
  • Chromones / therapeutic use
  • Clinical Trials as Topic
  • Cyclopropanes
  • Double-Blind Method
  • Humans
  • Hydroxyurea / analogs & derivatives
  • Hydroxyurea / pharmacology
  • Hydroxyurea / therapeutic use
  • Indoles
  • Leukotriene Antagonists* / pharmacology
  • Leukotriene Antagonists* / therapeutic use*
  • Leukotrienes / biosynthesis*
  • Lipoxygenase Inhibitors / pharmacology
  • Lipoxygenase Inhibitors / therapeutic use*
  • Membrane Lipids / metabolism
  • Membrane Proteins*
  • Phenylcarbamates
  • Phospholipases A / metabolism
  • Quinolines / pharmacology
  • Quinolines / therapeutic use
  • Randomized Controlled Trials as Topic
  • Receptors, Leukotriene*
  • Safety
  • Sulfides
  • Sulfonamides
  • Tosyl Compounds / pharmacology
  • Tosyl Compounds / therapeutic use

Substances

  • Acetates
  • Allergens
  • Anti-Asthmatic Agents
  • Chromones
  • Cyclopropanes
  • Indoles
  • Leukotriene Antagonists
  • Leukotrienes
  • Lipoxygenase Inhibitors
  • Membrane Lipids
  • Membrane Proteins
  • Phenylcarbamates
  • Quinolines
  • Receptors, Leukotriene
  • Sulfides
  • Sulfonamides
  • Tosyl Compounds
  • Arachidonic Acid
  • cysteinyl leukotriene receptor 2
  • Arachidonate 5-Lipoxygenase
  • Phospholipases A
  • leukotriene D4 receptor
  • montelukast
  • Aspirin
  • pranlukast
  • zileuton
  • Hydroxyurea
  • zafirlukast