Abstract
Seven gold complexes were prepared and investigated for biocidal activity against Gram-positive and -negative bacteria, fungi and protozoa. All of them were active against the tested microorganisms with the exception of Pseudomonas aeruginosa. In many, cases minimum inhibitory concentrations (MIC) were well below 1 microgram/ml. The activity is not simply related to the gold content, but also to the nature of both the phosphine and the aminothiol to which the metal is bound.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology
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Antitrichomonal Agents / chemical synthesis
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Antitrichomonal Agents / pharmacology
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Aspergillus niger / drug effects
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Candida albicans / drug effects
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Gold / chemistry*
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Gold / pharmacology*
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology
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Trichomonas / drug effects
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Antitrichomonal Agents
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Organometallic Compounds
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Gold