Abstract
Patients with cystic fibrosis (CF) suffer from chronic infective lung disease, which determines morbidity and mortality. While bacteria, such as Pseudomonas aeruginosa, are well-known to contribute to pulmonary pathology, the relevance of fungi in CF airways remains poorly understood. The best studied fungus in CF is Aspergillus fumigatus, which frequently colonizes CF airways and causes a disease condition termed allergic bronchopulmonary aspergillosis. This review aims to provide an update on the immunological mechanisms, diagnostic approaches and therapeutic strategies for allergic bronchopulmonary aspergillosis and other Aspergillus fumigatusmediated phenotypes in CF lung disease.
Keywords: Cystic fibrosis, Allergic Bronchopulmonary Aspergillosis (ABPA), Immune response.
Current Pharmaceutical Design
Title:Immune Response, Diagnosis and Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Lung Disease
Volume: 19 Issue: 20
Author(s): Olaf Eickmeier, Nikolaus Rieber, Jonas Eckrich, Andreas Hector, Ute Graeppler-Mainka and Dominik Hartl
Affiliation:
Keywords: Cystic fibrosis, Allergic Bronchopulmonary Aspergillosis (ABPA), Immune response.
Abstract: Patients with cystic fibrosis (CF) suffer from chronic infective lung disease, which determines morbidity and mortality. While bacteria, such as Pseudomonas aeruginosa, are well-known to contribute to pulmonary pathology, the relevance of fungi in CF airways remains poorly understood. The best studied fungus in CF is Aspergillus fumigatus, which frequently colonizes CF airways and causes a disease condition termed allergic bronchopulmonary aspergillosis. This review aims to provide an update on the immunological mechanisms, diagnostic approaches and therapeutic strategies for allergic bronchopulmonary aspergillosis and other Aspergillus fumigatusmediated phenotypes in CF lung disease.
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Eickmeier Olaf, Rieber Nikolaus, Eckrich Jonas, Hector Andreas, Graeppler-Mainka Ute and Hartl Dominik, Immune Response, Diagnosis and Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Lung Disease, Current Pharmaceutical Design 2013; 19 (20) . https://dx.doi.org/10.2174/13816128113199990349
DOI https://dx.doi.org/10.2174/13816128113199990349 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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