Chest
Clinical InvestigationsHigh Level of Interferon Gamma in Tuberculous Pleural Effusion
Section snippets
Patients
We studied 80 inpatients of our hospital with pleural effusion. These patients were classified according to their final diagnosis into five major groups.
Group 1: 30 patients with tuberculous pleural effusions. The diagnosis was confirmed by bacteriologic or histopathologic studies or both. Based on the estimated amount of pleural fluid as assessed by the size of the opacity on the chest roentgenogram, these patients were further divided into three groups: group A: small, less than one
RESULTS
Table 1 shows the total number of lymphocytes, percentage of T-lymphocytes (T3), T-helper-lymphocytes (T4), T-suppressor-lymphocytes (T8), and the helper/suppressor ratio (T4/T8) in pleural fluid and peripheral blood of patients with tuberculous, malignant and nonspecific pleural effusions. In all these groups, there is an increase in the percentage of T3 and T4 lymphocytes and an elevated T4/T8 ratio in the pleural fluid compared with these values in the peripheral blood. The absolute T3 and
DISCUSSION
The T-lymphocyte response plays an important role in the pathogenesis of clinical manifestations and control of tuberculosis.9 Tuberculous pleural effusions have an increased percentage and an increased absolute number of T-lymphocytes compared with peripheral blood.10 Other types of effusions also have increased percentages of T-lymphocytes but the absolute number of lymphocytes is not elevated.10, 11 Our results confirm these observations; we found an increase in both the absolute number and
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Expression Profile of Three Splicing Factors in Pleural Cells Based on the Underlying Etiology and Its Clinical Values in Patients with Pleural Effusion
2018, Translational OncologyCitation Excerpt :Few studies have demonstrated SRSF1-enhanced production of certain cytokines including type-1 interferons (INFs) [31]. A local immune deviation of PE showed a remarkable difference between TBPE and PNPE in concentrations of specific cytokines and accumulated immune cell proportion by the PE etiology including pathogens (Mycobacterium tuberculosis versus bacteria other than Mycobacterium species) [24,32]. For example, the concentration of INF-γ, a type-1 INF, in TBPE is higher than that in PNPE, and generally, TBPE has a higher proportion of lymphocytes than PNPE [24,32].
The diagnostic efficiency of QuantiFERONTB®-Gold test in the diagnosis of tuberculous pleurisy
2012, International Journal of MycobacteriologyMarkers for differentiation of tubercular pleural effusion from non-tubercular effusion
2011, Medical Journal Armed Forces IndiaTuberculosis and Atypical Mycobacterial Infections
2011, Tropical Infectious Diseases: Principles, Pathogens and PracticeDifferential diagnosis of tuberculous and malignant pleurisy using pleural fluid adenosine deaminase and interferon gamma in Taiwan
2011, Journal of Microbiology, Immunology and Infection
Supported in part by a grant from CIRIT (Ceneralitat de Catalunya) ana by Ortho Diagnostic Systems.
Manuscript received April 10; revision accepted July 20.