Chest
Clinical InvestigationsDesquamative Interstitial Pneumonitis in Children
Section snippets
Materials and Methods
Desquamative interstitial pneumonitis was identified in two ways. A review of approximately 2,500 cases of pneumonia in children from birth to 16 years of age between 1953 and 1971 revealed 38 cases of biopsy-proven interstitial pneumonitis or pulmonary fibrosis, or both. On microscopic examination of pulmonary tissue from these 38 cases, 12 cases of desquamative interstitial pneumonitis were discovered. Two additional cases were found in a review of the pathologic reports of pulmonary tissue
Results
The age at onset in 28 patients with desquamative interstitial pneumonitis is shown in Figure 2. It is a skewed distribution, with the age at onset being less than 1 year in 14 cases and between ages 2½ and 16 years in 14 cases. Five patients were boys and nine were girls in the group from the Mayo Clinic; seven were boys and seven were girls in the group from the literature.
Table 1 shows the frequency of initial symptoms and signs in the 14 patients from the Mayo Clinic, the 14 cases from the
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2009, Feigin and Cherry's Textbook of Pediatric Infectious Diseases, Sixth EditionInterstitial Lung Disease
2008, Pediatric Respiratory Medicine
Associate Professor of Pediatrics.
Associate Professor of Medicine.
Assistant Professor of Pathology.
Deceased.
Manuscript received May 11; revision accepted April 26