Chest
Original Research: Prolonged Mechanical VentilationSurvival of Patients With Kyphoscoliosis Receiving Mechanical Ventilation or Oxygen at Home
Section snippets
Materials and Methods
All Swedish men and women with respiratory failure due to nonparalytic kyphoscoliosis (ie, scoliosis not related to neuromuscular disorders) who commenced long-term oxygen therapy (LTOT) or HMV from January 1, 1996, to December 31, 2004, were eligible for inclusion in the study. All of the departments of respiratory medicine and all other medical units prescribing oxygen or HMV in all 24 Swedish counties agreed on the inclusion criteria and prospectively to register all patients who started
Results
The study group comprised 244 patients with kyphoscoliosis who were starting treatment with HMV or oxygen in Sweden during the study period. Their mean age was 69 ± 11 years; 167 were women and 77 were men. One hundred patients received HMV, and 27 of them also received supplementary oxygen therapy. Three patients were ventilated via tracheostomy, and the rest by nasal or oronasal masks. Mechanical ventilation was prescribed during sleep (ie, for < 8 h) to 75% of the patients and for > 12 h to
Discussion
Survival in patients who were treated with HMV was three times higher than that in patients who were treated with oxygen alone, even when adjusting for age, gender, concomitant respiratory diseases, and blood gas levels, in the present cohort of patients with respiratory insufficiency due to kyphoscoliosis. Survival was influenced by age and treatment modality but not by gender, concomitant respiratory disease, or the degree of hypoxia or hypercapnia before the onset of treatment.
Domiciliary
ACKNOWLEDGMENT
We thank all of the nurses and physicians who collected data.
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Domiciliary noninvasive ventilation for chronic respiratory diseases
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Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
The study was funded by grants from the Swedish Heart and Lung Foundation, the Swedish Board of Health and Welfare, and BREAS Medical AB.