Chest
Original ResearchReal-Time Electromagnetic Navigation Bronchoscopy to Peripheral Lung Lesions Using Overlaid CT Images: The First Human Study
Section snippets
Materials and Methods
Fifteen subjects (7 men and 8 women; age range, 26 to 81 years) were originally enrolled into an open-label, prospective, single-group, controlled clinical study from June 2003 to May 2004. The study was approved by the Tel Aviv Sourasky Medical Center Helsinki Committee, and informed consent was obtained from all the subjects prior to bronchoscopy. Bronchoscopy was performed on an outpatient basis under conscious sedation with midazolam or propofol. Patient selection was based on
Results
The SDBS navigation procedure was performed in 13 of the 15 originally enrolled subjects. One subject was dropped after severe bronchoconstriction developed as a result of propofol sedation, and the other subject was dropped for poor virtual bronchoscopy findings due to excessive mucopurulent secretions in the bronchial airways. Data from both subjects were excluded from the analyses.
The size of lesions was from 1.5 to 5 cm (average, 3.35 ± 1.1 cm) [Table 1]. The location of the lesions was as
Discussion
In the present study, we were able to show a high diagnostic yield using SDBS navigation for diagnosing peripheral pulmonary lesions. The diagnostic sensitivity of this procedure was as high as 69% in peripheral pulmonary lesions beyond the optical reach of the bronchoscope compared to the diagnostic sensitivity of flexible fiberoptic bronchoscopy (FFB) for small peripheral pulmonary lesions under radiographic fluoroscopic guidance, which has been < 35% in our institute. Moreover, the
References (35)
- et al.
Diagnosis of lung cancer: the guidelines
Chest
(2003) - et al.
Diagnostic accuracy in peripheral lung lesions: factors predicting success with flexible fiberoptic bronchoscopy
Chest
(1979) - et al.
Diagnostic accuracy in lung cancer: comparisons of techniques used in association with flexible fiberoptic bronchoscopy
Chest
(1976) - et al.
Performance characteristics of different modalities for diagnosis of suspected lung cancer: summary of published evidence
Chest
(2003) - et al.
Diagnostic yield of fiberoptic bronchoscopy in evaluating solitary pulmonary nodules
Chest
(2000) Bronchoscopic diagnosis of solitary pulmonary nodules and lung masses in the absence of endobronchial abnormality
Chest
(1996)Diagnostic fiberoptic bronchoscopy: techniques and results of biopsy in 600 patients
Chest
(1975)- et al.
The effect of tumor size and location on diagnosis by fiberoptic bronchoscopy
Chest
(1977) - et al.
Biopsy and brushing of peripheral lung cancer with fluoroscopic guidance
Chest
(1979) - et al.
Diagnosis of peripheral lung cancer in cases of tumors 2 cm or less in size
Chest
(1989)
The utility of fiberoptic bronchoscopy in the evaluation of the solitary pulmonary nodule
Chest
Fine-needle aspiration cytologic technique for lung cancer has a high potential of malignant cell spread through the tract
Chest
Transbronchial needle aspiration in the practice of bronchoscopy
Mayo Clin Proc
The value of transbronchial needle aspiration in the diagnosis of peripheral pulmonary lesions
Chest
Three-dimensional CT-guided bronchoscopy with a real-time electromagnetic position sensor: a comparison of two image registration methods
Chest
Real-time bronchoscope tip localization enables three-dimensional CT image guidance for transbronchial needle aspiration in swine
Chest
CT-guided transbronchial biopsy using an ultrathin bronchoscope with virtual bronchoscopic navigation
Chest
Cited by (290)
Augmented Reality Navigation System for Biliary Interventional Procedures With Dynamic Respiratory Motion Correction
2024, IEEE Transactions on Biomedical EngineeringRobotic-assisted Navigation Bronchoscopy A Meta-Analysis of Diagnostic Yield and Complications
2024, Journal of Bronchology and Interventional PulmonologyA novel approach to wireless electromagnetic tracking using frequency modulation radio communication
2023, International Journal of Computer Assisted Radiology and Surgery
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
Grant support was provided by superDimension, Ltd, Hertzliya, Israel.