Chest
Clinical InvestigationsCardiologyFeasibility of Routine Pulmonary Arterial Impedance Measurements in Pulmonary Hypertension
Section snippets
Study Population
Twenty-two patients (5 men and 17 women; mean age, 46 years) with PAH gave informed consent to participate in this study, which was approved by the Institutional Review Board of the Erasme University Hospital. PAH was defined by an increase in Ppa values without identifiable cardiac or pulmonary cause, and possibly associated with conditions such as appetite-suppressant intake, connective tissue disease, liver cirrhosis, HIV infection, and congenital left-to-right shunts, as defined by a World
Effects of Pulmonary Hypertension
As shown in Table 1, the patients had increased levels of Ppa, Pra, and PVR, a normal Ppao level, and decreased cardiac output, with a PVZ spectrum showing marked increases in Z0, Z1, and Zc, a shift of Fmin to higher frequencies, and a negative first harmonic phase angle, with Z0 cross-shifted to higher frequencies (Table 1). Representative PVZ spectra with source pressure and flow signals are shown in FIGURE 1, FIGURE 2, FIGURE 3.
Compared to previously reported primary pulmonary hypertension
DISCUSSION
The present results show that it is possible to analyze Ppa and flow waves obtained during routine right heart catheterization with thermodilution fluid-filled pulmonary artery catheters and concomitant transthoracic Doppler echocardiography. Derived PVZ spectra are realistic, as they were similar to those previously reported with sophisticated high-fidelity equipment, and were sensitive to pharmacologic interventions.
Right heart catheterization for the diagnosis and therapeutic follow-up of
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This research was supported by grant No. 3.4516.02 from the Fonds de la Recherche Scientifique Médicale and by the Foundation for Cardiac Surgery, Belgium. Sandrine Huez is fellow of the Fonds National de la Recherche Scientifique, Belgium.
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