Chest
Clinical InvestigationsSLEEP AND BREATHINGNocturnal Oxygen Desaturation Correlates With the Severity of Coronary Atherosclerosis in Coronary Artery Disease
Section snippets
Patients
All patients with ischemic heart disease who were hospitalized at Shinshu University Hospital between June 2000 and October 2001 for the diagnosis of chest pain or for the follow-up of old myocardial infarction by cardiac catheterization were considered candidates for the present study. Fifty-nine consecutive patients with angiographically diagnosed cardiovascular disease (angina pectoris, 30 patients [23 men and 7 women]; old myocardial infarction, 29 patients [25 men and 4 women]) were
Results
Clinical characteristics and serum profiles of patients in the three study groups are summarized in Table 1. There were no significant between-group differences in age, the incidence of angina pectoris or old myocardial infarction, smoking history, or body mass index. Neither were there significant differences in the frequency of hypertension, diabetes, or hyperlipidemia, or in levels of HbAIc, triglycerides, HDL-C, or uric acid. The only significant difference seen for traditional coronary
Discussion
It has been shown that patients with cardiovascular disease have a high prevalence of SDB and of oxygen desaturation accompanied by SDB.17,18 A temporal association exists between nocturnal myocardial ischemia and sleep apnea and hypopnea or desaturation in some patients with nocturnal ST-segment depression.10 Thus, SDB may be an independent predictor of cardiovascular disease. In the present study, patients with ischemic heart disease had a high prevalence of increased NOD events (> 5 events
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